from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3762c/-

LFCtreatmentdescriptionclass of inhibitor

-1.056

Amikacinug/mL Amikacintranslation

-0.384

Cap5-10ug/mL Capreomycintranslation

-1.491

Rox10-50 ug/mL Roxithromycintranslation

-0.798

SM2-5 ug/mL Streptomycintranslation

-1.431

Tet5-10 ug/mL Tetracyclinetranslation

0.691

Rif0.2-5ug/mL Rifampicintranscription

-0.373

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.073

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.377

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.031

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.066

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.214

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.580

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.032

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.067

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.495

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.311

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.058

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.433

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.463

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.369

KCN5-20 ug/mL Potassium cyaniderespiration

-0.213

NaN30.2-2 mM Sodium aziderespiration

-0.299

Nigericin50 uM Nigericinrespiration

0.104

TRC10-150 ug/mL Triclosanrespiration

-0.475

TRZ10-25 ug/mL Thioridazinerespiration

-1.690

Valinomycin0.5-10 uM Valinomycinrespiration

-1.148

ZnSO42 mM ZnSO4respiration

-0.250

menadione6-10 ug/mL Menadionerespiration

0.247

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.251

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.595

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.547

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.652

NRP_1Non-replicating persistence stage 1dosRassociated

0.347

Amp0.2mg/mL AmpicillincellWall

0.199

Cephalexin20-100 ug/mL CephalexincellWall

-0.497

Cerulenin0.32-5 ug/mL CerulenincellWall

1.083

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.681

EMB10-20 ug/mL EthambutolcellWall

-0.889

Eta12-40 ug/mL EthionamidecellWall

-1.065

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.309

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.091

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.463

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.625

BZA0.12 mg/mL BenzamidearomaticAmides

0.747

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.065

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.377

H2O24 mM hydrogen peroxideDNAdamaging

-0.835

Levo10 ug/mL LevofloxacinDNAdamaging

0.263

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.061

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.772

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.598

UVUV-irradiationDNAdamaging

0.251

ARP41-4 ug/mL Antitubercular compound ARP4?

0.184

Antimycin12.5-50 ug/mL Antimycin A?

-0.330

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.678

PA_110-50 ug/mL Antitubercular compound PA-1?

0.813

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.194

PA8240.2-2 ug/mL PA-824?

-0.221

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.156

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.523

Verapamil50 uM Verapamil?

0.214

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.974

methoxatin10-20 ug/mL Methoxatin?