from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3752c/-

LFCtreatmentdescriptionclass of inhibitor

1.135

Amikacinug/mL Amikacintranslation

1.777

Cap5-10ug/mL Capreomycintranslation

1.753

Rox10-50 ug/mL Roxithromycintranslation

0.285

SM2-5 ug/mL Streptomycintranslation

1.547

Tet5-10 ug/mL Tetracyclinetranslation

0.203

Rif0.2-5ug/mL Rifampicintranscription

-0.072

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.932

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.350

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.012

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.725

Clofazimine10-13 ug/mL Clofaziminerespiration

0.539

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.878

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.864

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.173

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

1.265

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.507

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.409

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.656

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.460

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.482

Nigericin50 uM Nigericinrespiration

-0.077

TRC10-150 ug/mL Triclosanrespiration

-0.872

TRZ10-25 ug/mL Thioridazinerespiration

-0.081

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.632

menadione6-10 ug/mL Menadionerespiration

-0.237

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.337

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.485

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.671

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.501

NRP_1Non-replicating persistence stage 1dosRassociated

0.681

Amp0.2mg/mL AmpicillincellWall

-0.511

Cephalexin20-100 ug/mL CephalexincellWall

1.040

Cerulenin0.32-5 ug/mL CerulenincellWall

0.333

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.301

EMB10-20 ug/mL EthambutolcellWall

0.193

Eta12-40 ug/mL EthionamidecellWall

0.003

INH0.2-0.4 ug/mL IsoniazidcellWall

0.048

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.643

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.301

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.494

BZA0.12 mg/mL BenzamidearomaticAmides

-0.263

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.371

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.271

H2O24 mM hydrogen peroxideDNAdamaging

0.031

Levo10 ug/mL LevofloxacinDNAdamaging

0.739

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.539

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.531

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.377

UVUV-irradiationDNAdamaging

-0.999

ARP41-4 ug/mL Antitubercular compound ARP4?

0.205

Antimycin12.5-50 ug/mL Antimycin A?

-0.460

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.926

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.191

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.755

PA8240.2-2 ug/mL PA-824?

-1.308

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.910

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

-0.480

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.498

methoxatin10-20 ug/mL Methoxatin?