from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3744/nmtR

LFCtreatmentdescriptionclass of inhibitor

0.469

Amikacinug/mL Amikacintranslation

0.995

Cap5-10ug/mL Capreomycintranslation

-0.112

Rox10-50 ug/mL Roxithromycintranslation

0.893

SM2-5 ug/mL Streptomycintranslation

2.577

Tet5-10 ug/mL Tetracyclinetranslation

0.809

Rif0.2-5ug/mL Rifampicintranscription

-0.688

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.246

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.096

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.753

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.247

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.345

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.275

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.696

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.322

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.972

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.721

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.488

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.396

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.963

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.777

KCN5-20 ug/mL Potassium cyaniderespiration

-0.842

NaN30.2-2 mM Sodium aziderespiration

-0.057

Nigericin50 uM Nigericinrespiration

-0.351

TRC10-150 ug/mL Triclosanrespiration

-0.824

TRZ10-25 ug/mL Thioridazinerespiration

-0.339

Valinomycin0.5-10 uM Valinomycinrespiration

0.796

ZnSO42 mM ZnSO4respiration

1.243

menadione6-10 ug/mL Menadionerespiration

0.052

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.082

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.606

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.223

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

2.042

NRP_1Non-replicating persistence stage 1dosRassociated

0.416

Amp0.2mg/mL AmpicillincellWall

-0.331

Cephalexin20-100 ug/mL CephalexincellWall

-0.095

Cerulenin0.32-5 ug/mL CerulenincellWall

0.279

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.777

EMB10-20 ug/mL EthambutolcellWall

-0.026

Eta12-40 ug/mL EthionamidecellWall

0.109

INH0.2-0.4 ug/mL IsoniazidcellWall

0.462

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.032

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.936

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.573

BZA0.12 mg/mL BenzamidearomaticAmides

0.197

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.205

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.321

H2O24 mM hydrogen peroxideDNAdamaging

-0.165

Levo10 ug/mL LevofloxacinDNAdamaging

0.241

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.314

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.331

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.414

UVUV-irradiationDNAdamaging

-1.150

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.285

Antimycin12.5-50 ug/mL Antimycin A?

0.025

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.485

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.501

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.347

PA8240.2-2 ug/mL PA-824?

1.562

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.452

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.076

Verapamil50 uM Verapamil?

-0.443

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.086

methoxatin10-20 ug/mL Methoxatin?