from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3728/-

LFCtreatmentdescriptionclass of inhibitor

0.662

Amikacinug/mL Amikacintranslation

0.632

Cap5-10ug/mL Capreomycintranslation

0.459

Rox10-50 ug/mL Roxithromycintranslation

0.145

SM2-5 ug/mL Streptomycintranslation

2.068

Tet5-10 ug/mL Tetracyclinetranslation

0.872

Rif0.2-5ug/mL Rifampicintranscription

0.158

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.149

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.435

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.572

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.110

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.024

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.399

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.736

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.669

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.188

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.200

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.768

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.341

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.576

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.379

KCN5-20 ug/mL Potassium cyaniderespiration

0.441

NaN30.2-2 mM Sodium aziderespiration

0.158

Nigericin50 uM Nigericinrespiration

1.161

TRC10-150 ug/mL Triclosanrespiration

0.009

TRZ10-25 ug/mL Thioridazinerespiration

0.309

Valinomycin0.5-10 uM Valinomycinrespiration

-0.645

ZnSO42 mM ZnSO4respiration

0.731

menadione6-10 ug/mL Menadionerespiration

-0.032

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.573

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.398

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.081

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.082

NRP_1Non-replicating persistence stage 1dosRassociated

0.315

Amp0.2mg/mL AmpicillincellWall

0.048

Cephalexin20-100 ug/mL CephalexincellWall

-0.328

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.298

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.417

EMB10-20 ug/mL EthambutolcellWall

-0.172

Eta12-40 ug/mL EthionamidecellWall

0.111

INH0.2-0.4 ug/mL IsoniazidcellWall

0.355

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.138

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.088

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.167

BZA0.12 mg/mL BenzamidearomaticAmides

-0.215

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.257

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.512

H2O24 mM hydrogen peroxideDNAdamaging

0.248

Levo10 ug/mL LevofloxacinDNAdamaging

-1.030

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.064

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.260

Oflox5-10 ug/mL OfloxacinDNAdamaging

-1.353

UVUV-irradiationDNAdamaging

1.041

ARP41-4 ug/mL Antitubercular compound ARP4?

0.461

Antimycin12.5-50 ug/mL Antimycin A?

0.029

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.327

PA_110-50 ug/mL Antitubercular compound PA-1?

0.361

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.031

PA8240.2-2 ug/mL PA-824?

-1.427

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-1.239

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.240

Verapamil50 uM Verapamil?

0.559

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.212

methoxatin10-20 ug/mL Methoxatin?