from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3715c/recR

LFCtreatmentdescriptionclass of inhibitor

3.054

Amikacinug/mL Amikacintranslation

2.285

Cap5-10ug/mL Capreomycintranslation

3.689

Rox10-50 ug/mL Roxithromycintranslation

0.757

SM2-5 ug/mL Streptomycintranslation

2.459

Tet5-10 ug/mL Tetracyclinetranslation

0.273

Rif0.2-5ug/mL Rifampicintranscription

-0.534

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.690

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.368

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.601

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.618

Clofazimine10-13 ug/mL Clofaziminerespiration

0.048

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.947

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.231

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.731

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.096

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.114

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.740

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.459

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.322

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.735

KCN5-20 ug/mL Potassium cyaniderespiration

-0.183

NaN30.2-2 mM Sodium aziderespiration

0.103

Nigericin50 uM Nigericinrespiration

-0.541

TRC10-150 ug/mL Triclosanrespiration

-0.465

TRZ10-25 ug/mL Thioridazinerespiration

-0.889

Valinomycin0.5-10 uM Valinomycinrespiration

0.468

ZnSO42 mM ZnSO4respiration

0.618

menadione6-10 ug/mL Menadionerespiration

-0.083

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.366

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.189

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.199

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.369

NRP_1Non-replicating persistence stage 1dosRassociated

0.449

Amp0.2mg/mL AmpicillincellWall

0.852

Cephalexin20-100 ug/mL CephalexincellWall

0.555

Cerulenin0.32-5 ug/mL CerulenincellWall

0.046

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.436

EMB10-20 ug/mL EthambutolcellWall

0.729

Eta12-40 ug/mL EthionamidecellWall

1.094

INH0.2-0.4 ug/mL IsoniazidcellWall

0.355

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.387

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.247

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.320

BZA0.12 mg/mL BenzamidearomaticAmides

-0.563

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.417

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.527

H2O24 mM hydrogen peroxideDNAdamaging

0.583

Levo10 ug/mL LevofloxacinDNAdamaging

-0.210

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.428

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.051

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.345

UVUV-irradiationDNAdamaging

-0.421

ARP41-4 ug/mL Antitubercular compound ARP4?

0.254

Antimycin12.5-50 ug/mL Antimycin A?

0.784

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.041

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.294

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.686

PA8240.2-2 ug/mL PA-824?

-0.322

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.150

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.268

Verapamil50 uM Verapamil?

0.705

mercaptoethanol2 mM 2-Mercaptoethanol?

0.140

methoxatin10-20 ug/mL Methoxatin?