from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3711c/dnaQ

LFCtreatmentdescriptionclass of inhibitor

-0.238

Amikacinug/mL Amikacintranslation

0.451

Cap5-10ug/mL Capreomycintranslation

-0.038

Rox10-50 ug/mL Roxithromycintranslation

0.688

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

-0.082

Rif0.2-5ug/mL Rifampicintranscription

-0.530

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.384

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.155

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.257

CPZ10-50 ug/mL Chlorpromazinerespiration

0.123

Clofazimine10-13 ug/mL Clofaziminerespiration

0.035

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.587

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.580

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.960

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.054

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.405

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.859

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.015

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.315

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.338

KCN5-20 ug/mL Potassium cyaniderespiration

0.651

NaN30.2-2 mM Sodium aziderespiration

0.021

Nigericin50 uM Nigericinrespiration

-0.386

TRC10-150 ug/mL Triclosanrespiration

0.290

TRZ10-25 ug/mL Thioridazinerespiration

-1.969

Valinomycin0.5-10 uM Valinomycinrespiration

0.536

ZnSO42 mM ZnSO4respiration

-0.395

menadione6-10 ug/mL Menadionerespiration

-0.193

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.114

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.791

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.429

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.407

NRP_1Non-replicating persistence stage 1dosRassociated

0.333

Amp0.2mg/mL AmpicillincellWall

0.430

Cephalexin20-100 ug/mL CephalexincellWall

-0.483

Cerulenin0.32-5 ug/mL CerulenincellWall

0.510

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.405

EMB10-20 ug/mL EthambutolcellWall

1.305

Eta12-40 ug/mL EthionamidecellWall

0.757

INH0.2-0.4 ug/mL IsoniazidcellWall

0.234

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.083

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.963

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.383

BZA0.12 mg/mL BenzamidearomaticAmides

0.162

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.048

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.986

H2O24 mM hydrogen peroxideDNAdamaging

0.179

Levo10 ug/mL LevofloxacinDNAdamaging

-0.625

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.331

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.206

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.246

UVUV-irradiationDNAdamaging

-0.813

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.722

Antimycin12.5-50 ug/mL Antimycin A?

1.169

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.627

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.421

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.911

PA8240.2-2 ug/mL PA-824?

1.724

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.027

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.100

Verapamil50 uM Verapamil?

0.068

mercaptoethanol2 mM 2-Mercaptoethanol?

0.600

methoxatin10-20 ug/mL Methoxatin?