from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3692/moxR2

LFCtreatmentdescriptionclass of inhibitor

-1.022

Amikacinug/mL Amikacintranslation

-2.229

Cap5-10ug/mL Capreomycintranslation

-2.028

Rox10-50 ug/mL Roxithromycintranslation

-0.678

SM2-5 ug/mL Streptomycintranslation

-0.025

Tet5-10 ug/mL Tetracyclinetranslation

-0.068

Rif0.2-5ug/mL Rifampicintranscription

-0.764

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.468

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.861

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.707

CPZ10-50 ug/mL Chlorpromazinerespiration

0.239

Clofazimine10-13 ug/mL Clofaziminerespiration

0.124

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.966

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.648

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.256

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.183

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.073

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.754

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.489

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.273

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.338

KCN5-20 ug/mL Potassium cyaniderespiration

0.054

NaN30.2-2 mM Sodium aziderespiration

0.886

Nigericin50 uM Nigericinrespiration

-0.401

TRC10-150 ug/mL Triclosanrespiration

-0.322

TRZ10-25 ug/mL Thioridazinerespiration

-2.910

Valinomycin0.5-10 uM Valinomycinrespiration

0.265

ZnSO42 mM ZnSO4respiration

-1.444

menadione6-10 ug/mL Menadionerespiration

0.364

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.602

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.506

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.751

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.174

NRP_1Non-replicating persistence stage 1dosRassociated

0.919

Amp0.2mg/mL AmpicillincellWall

1.008

Cephalexin20-100 ug/mL CephalexincellWall

-0.359

Cerulenin0.32-5 ug/mL CerulenincellWall

0.745

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.455

EMB10-20 ug/mL EthambutolcellWall

0.490

Eta12-40 ug/mL EthionamidecellWall

0.166

INH0.2-0.4 ug/mL IsoniazidcellWall

0.315

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.075

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.680

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.557

BZA0.12 mg/mL BenzamidearomaticAmides

0.026

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.181

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.048

H2O24 mM hydrogen peroxideDNAdamaging

-0.631

Levo10 ug/mL LevofloxacinDNAdamaging

0.118

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.582

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.144

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.015

UVUV-irradiationDNAdamaging

-0.680

ARP41-4 ug/mL Antitubercular compound ARP4?

0.053

Antimycin12.5-50 ug/mL Antimycin A?

1.177

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.512

PA_110-50 ug/mL Antitubercular compound PA-1?

0.332

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.040

PA8240.2-2 ug/mL PA-824?

-0.534

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.398

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

1.043

Verapamil50 uM Verapamil?

1.340

mercaptoethanol2 mM 2-Mercaptoethanol?

0.454

methoxatin10-20 ug/mL Methoxatin?