from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3672c/-

LFCtreatmentdescriptionclass of inhibitor

1.169

Amikacinug/mL Amikacintranslation

-0.190

Cap5-10ug/mL Capreomycintranslation

0.920

Rox10-50 ug/mL Roxithromycintranslation

1.047

SM2-5 ug/mL Streptomycintranslation

2.247

Tet5-10 ug/mL Tetracyclinetranslation

-1.541

Rif0.2-5ug/mL Rifampicintranscription

-1.203

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.172

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.418

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.196

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.385

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.162

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.494

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.159

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.872

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.046

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.510

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.391

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.379

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.145

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.568

KCN5-20 ug/mL Potassium cyaniderespiration

-0.024

NaN30.2-2 mM Sodium aziderespiration

0.462

Nigericin50 uM Nigericinrespiration

-0.056

TRC10-150 ug/mL Triclosanrespiration

-1.044

TRZ10-25 ug/mL Thioridazinerespiration

-0.001

Valinomycin0.5-10 uM Valinomycinrespiration

-0.268

ZnSO42 mM ZnSO4respiration

0.791

menadione6-10 ug/mL Menadionerespiration

0.346

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.023

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.430

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.129

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.595

NRP_1Non-replicating persistence stage 1dosRassociated

0.395

Amp0.2mg/mL AmpicillincellWall

0.312

Cephalexin20-100 ug/mL CephalexincellWall

-1.101

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.410

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.142

EMB10-20 ug/mL EthambutolcellWall

-0.303

Eta12-40 ug/mL EthionamidecellWall

0.060

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.817

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.259

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.289

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.576

BZA0.12 mg/mL BenzamidearomaticAmides

0.163

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.780

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.455

H2O24 mM hydrogen peroxideDNAdamaging

0.116

Levo10 ug/mL LevofloxacinDNAdamaging

-0.407

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.590

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.299

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.273

UVUV-irradiationDNAdamaging

-0.579

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.357

Antimycin12.5-50 ug/mL Antimycin A?

-0.046

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.224

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.561

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.155

PA8240.2-2 ug/mL PA-824?

0.472

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.286

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.282

Verapamil50 uM Verapamil?

-0.559

mercaptoethanol2 mM 2-Mercaptoethanol?

0.090

methoxatin10-20 ug/mL Methoxatin?