from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3610c/ftsH

LFCtreatmentdescriptionclass of inhibitor

-1.037

Amikacinug/mL Amikacintranslation

0.344

Cap5-10ug/mL Capreomycintranslation

0.210

Rox10-50 ug/mL Roxithromycintranslation

-0.060

SM2-5 ug/mL Streptomycintranslation

0.961

Tet5-10 ug/mL Tetracyclinetranslation

-0.214

Rif0.2-5ug/mL Rifampicintranscription

-0.879

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.041

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.792

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.687

CPZ10-50 ug/mL Chlorpromazinerespiration

0.575

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.114

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

3.436

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.507

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.015

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.213

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.358

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.766

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.109

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.133

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.244

KCN5-20 ug/mL Potassium cyaniderespiration

-0.269

NaN30.2-2 mM Sodium aziderespiration

1.028

Nigericin50 uM Nigericinrespiration

0.874

TRC10-150 ug/mL Triclosanrespiration

1.099

TRZ10-25 ug/mL Thioridazinerespiration

2.016

Valinomycin0.5-10 uM Valinomycinrespiration

-0.636

ZnSO42 mM ZnSO4respiration

0.692

menadione6-10 ug/mL Menadionerespiration

-0.484

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.646

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.934

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.915

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.460

NRP_1Non-replicating persistence stage 1dosRassociated

0.040

Amp0.2mg/mL AmpicillincellWall

-0.653

Cephalexin20-100 ug/mL CephalexincellWall

-0.011

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.370

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.365

EMB10-20 ug/mL EthambutolcellWall

0.159

Eta12-40 ug/mL EthionamidecellWall

-0.293

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.075

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.182

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.150

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.522

BZA0.12 mg/mL BenzamidearomaticAmides

-0.108

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.316

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.750

H2O24 mM hydrogen peroxideDNAdamaging

-0.458

Levo10 ug/mL LevofloxacinDNAdamaging

-0.339

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.665

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.135

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.308

UVUV-irradiationDNAdamaging

1.226

ARP41-4 ug/mL Antitubercular compound ARP4?

-1.092

Antimycin12.5-50 ug/mL Antimycin A?

-0.543

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.578

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.836

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.735

PA8240.2-2 ug/mL PA-824?

1.395

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.159

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.307

Verapamil50 uM Verapamil?

-0.657

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.540

methoxatin10-20 ug/mL Methoxatin?