from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3556c/fadA6

LFCtreatmentdescriptionclass of inhibitor

-0.389

Amikacinug/mL Amikacintranslation

-0.356

Cap5-10ug/mL Capreomycintranslation

-0.023

Rox10-50 ug/mL Roxithromycintranslation

1.101

SM2-5 ug/mL Streptomycintranslation

-0.788

Tet5-10 ug/mL Tetracyclinetranslation

0.952

Rif0.2-5ug/mL Rifampicintranscription

-0.567

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.678

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.005

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.352

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.058

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.409

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.511

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.958

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.969

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.926

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.006

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.282

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.638

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.679

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.367

KCN5-20 ug/mL Potassium cyaniderespiration

-0.023

NaN30.2-2 mM Sodium aziderespiration

0.420

Nigericin50 uM Nigericinrespiration

-0.693

TRC10-150 ug/mL Triclosanrespiration

0.582

TRZ10-25 ug/mL Thioridazinerespiration

-0.102

Valinomycin0.5-10 uM Valinomycinrespiration

0.279

ZnSO42 mM ZnSO4respiration

-1.478

menadione6-10 ug/mL Menadionerespiration

1.716

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.012

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.691

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.117

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.269

NRP_1Non-replicating persistence stage 1dosRassociated

0.267

Amp0.2mg/mL AmpicillincellWall

-0.406

Cephalexin20-100 ug/mL CephalexincellWall

-0.189

Cerulenin0.32-5 ug/mL CerulenincellWall

0.702

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.000

EMB10-20 ug/mL EthambutolcellWall

-0.344

Eta12-40 ug/mL EthionamidecellWall

-0.158

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.243

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.082

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.211

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.065

BZA0.12 mg/mL BenzamidearomaticAmides

0.403

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.075

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.689

H2O24 mM hydrogen peroxideDNAdamaging

-0.060

Levo10 ug/mL LevofloxacinDNAdamaging

0.622

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.641

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.341

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.984

UVUV-irradiationDNAdamaging

-0.753

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.522

Antimycin12.5-50 ug/mL Antimycin A?

-0.429

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.847

PA_110-50 ug/mL Antitubercular compound PA-1?

-1.140

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.202

PA8240.2-2 ug/mL PA-824?

0.049

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.225

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.737

Verapamil50 uM Verapamil?

-1.162

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.549

methoxatin10-20 ug/mL Methoxatin?