from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3555c/-

LFCtreatmentdescriptionclass of inhibitor

0.281

Amikacinug/mL Amikacintranslation

-0.771

Cap5-10ug/mL Capreomycintranslation

-0.602

Rox10-50 ug/mL Roxithromycintranslation

0.370

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

0.512

Rif0.2-5ug/mL Rifampicintranscription

0.055

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.671

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.897

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.252

CPZ10-50 ug/mL Chlorpromazinerespiration

0.146

Clofazimine10-13 ug/mL Clofaziminerespiration

0.399

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.874

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.043

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.870

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-1.103

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.241

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.980

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.460

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.704

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.427

Nigericin50 uM Nigericinrespiration

-0.194

TRC10-150 ug/mL Triclosanrespiration

-0.191

TRZ10-25 ug/mL Thioridazinerespiration

-0.173

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.151

menadione6-10 ug/mL Menadionerespiration

0.084

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.264

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.372

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.137

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.596

NRP_1Non-replicating persistence stage 1dosRassociated

0.478

Amp0.2mg/mL AmpicillincellWall

-0.659

Cephalexin20-100 ug/mL CephalexincellWall

0.556

Cerulenin0.32-5 ug/mL CerulenincellWall

0.342

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.520

EMB10-20 ug/mL EthambutolcellWall

0.534

Eta12-40 ug/mL EthionamidecellWall

-0.111

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.154

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.738

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.910

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.050

BZA0.12 mg/mL BenzamidearomaticAmides

-0.219

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.018

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

1.070

H2O24 mM hydrogen peroxideDNAdamaging

0.204

Levo10 ug/mL LevofloxacinDNAdamaging

0.723

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.055

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.106

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.781

UVUV-irradiationDNAdamaging

-0.302

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.638

Antimycin12.5-50 ug/mL Antimycin A?

-0.980

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.040

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.370

PA_2110-50 ug/mL Antitubercular compound PA-21?

2.029

PA8240.2-2 ug/mL PA-824?

0.027

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.239

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.113

Verapamil50 uM Verapamil?

-0.733

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.987

methoxatin10-20 ug/mL Methoxatin?