from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3530c/-

LFCtreatmentdescriptionclass of inhibitor

0.556

Amikacinug/mL Amikacintranslation

-0.150

Cap5-10ug/mL Capreomycintranslation

-0.415

Rox10-50 ug/mL Roxithromycintranslation

-1.593

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

-0.003

Rif0.2-5ug/mL Rifampicintranscription

-0.204

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.453

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.504

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.641

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.976

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.416

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.417

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.841

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.130

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.315

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.425

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.806

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.181

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

2.195

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.548

Nigericin50 uM Nigericinrespiration

0.435

TRC10-150 ug/mL Triclosanrespiration

-1.018

TRZ10-25 ug/mL Thioridazinerespiration

-0.349

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-1.504

menadione6-10 ug/mL Menadionerespiration

2.724

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.549

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.031

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.173

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.094

NRP_1Non-replicating persistence stage 1dosRassociated

-0.388

Amp0.2mg/mL AmpicillincellWall

-0.481

Cephalexin20-100 ug/mL CephalexincellWall

-0.236

Cerulenin0.32-5 ug/mL CerulenincellWall

0.109

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.076

EMB10-20 ug/mL EthambutolcellWall

-0.518

Eta12-40 ug/mL EthionamidecellWall

-0.408

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.614

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.384

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.514

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.118

BZA0.12 mg/mL BenzamidearomaticAmides

0.310

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.275

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.228

H2O24 mM hydrogen peroxideDNAdamaging

-0.398

Levo10 ug/mL LevofloxacinDNAdamaging

0.335

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.602

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.214

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.065

UVUV-irradiationDNAdamaging

-0.867

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.392

Antimycin12.5-50 ug/mL Antimycin A?

-0.634

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.183

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.266

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.938

PA8240.2-2 ug/mL PA-824?

1.432

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.357

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.187

Verapamil50 uM Verapamil?

-1.376

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.187

methoxatin10-20 ug/mL Methoxatin?