from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3523/ltp3

LFCtreatmentdescriptionclass of inhibitor

0.227

Amikacinug/mL Amikacintranslation

1.451

Cap5-10ug/mL Capreomycintranslation

-0.188

Rox10-50 ug/mL Roxithromycintranslation

0.452

SM2-5 ug/mL Streptomycintranslation

-0.574

Tet5-10 ug/mL Tetracyclinetranslation

1.169

Rif0.2-5ug/mL Rifampicintranscription

0.837

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.972

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.369

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.145

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.443

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.922

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.996

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.722

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-2.261

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.435

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.764

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.205

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.262

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.218

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.911

KCN5-20 ug/mL Potassium cyaniderespiration

-0.045

NaN30.2-2 mM Sodium aziderespiration

-0.246

Nigericin50 uM Nigericinrespiration

-0.322

TRC10-150 ug/mL Triclosanrespiration

0.181

TRZ10-25 ug/mL Thioridazinerespiration

-0.838

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-1.077

menadione6-10 ug/mL Menadionerespiration

2.374

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.441

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.381

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.106

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.140

NRP_1Non-replicating persistence stage 1dosRassociated

-0.394

Amp0.2mg/mL AmpicillincellWall

-0.003

Cephalexin20-100 ug/mL CephalexincellWall

0.554

Cerulenin0.32-5 ug/mL CerulenincellWall

0.148

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.051

EMB10-20 ug/mL EthambutolcellWall

-0.006

Eta12-40 ug/mL EthionamidecellWall

-0.036

INH0.2-0.4 ug/mL IsoniazidcellWall

0.376

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.735

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.522

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.377

BZA0.12 mg/mL BenzamidearomaticAmides

0.011

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.021

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.099

H2O24 mM hydrogen peroxideDNAdamaging

0.090

Levo10 ug/mL LevofloxacinDNAdamaging

-0.299

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.211

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.102

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.047

UVUV-irradiationDNAdamaging

-0.493

ARP41-4 ug/mL Antitubercular compound ARP4?

0.243

Antimycin12.5-50 ug/mL Antimycin A?

-0.122

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.299

PA_110-50 ug/mL Antitubercular compound PA-1?

0.279

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.838

PA8240.2-2 ug/mL PA-824?

-0.121

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.241

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.120

Verapamil50 uM Verapamil?

-0.296

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.453

methoxatin10-20 ug/mL Methoxatin?