from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3515c/fadD19

LFCtreatmentdescriptionclass of inhibitor

0.211

Amikacinug/mL Amikacintranslation

-0.073

Cap5-10ug/mL Capreomycintranslation

0.398

Rox10-50 ug/mL Roxithromycintranslation

1.734

SM2-5 ug/mL Streptomycintranslation

-0.400

Tet5-10 ug/mL Tetracyclinetranslation

-0.376

Rif0.2-5ug/mL Rifampicintranscription

-0.321

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.991

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.533

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.033

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.146

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.453

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.691

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.368

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.116

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.364

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.548

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.305

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.122

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.159

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.019

KCN5-20 ug/mL Potassium cyaniderespiration

-1.032

NaN30.2-2 mM Sodium aziderespiration

0.180

Nigericin50 uM Nigericinrespiration

0.742

TRC10-150 ug/mL Triclosanrespiration

0.161

TRZ10-25 ug/mL Thioridazinerespiration

0.468

Valinomycin0.5-10 uM Valinomycinrespiration

-0.393

ZnSO42 mM ZnSO4respiration

-0.295

menadione6-10 ug/mL Menadionerespiration

4.121

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.467

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.292

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.187

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.534

NRP_1Non-replicating persistence stage 1dosRassociated

0.073

Amp0.2mg/mL AmpicillincellWall

-0.447

Cephalexin20-100 ug/mL CephalexincellWall

-0.217

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.288

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.351

EMB10-20 ug/mL EthambutolcellWall

-0.583

Eta12-40 ug/mL EthionamidecellWall

-0.364

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.532

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.148

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.313

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.129

BZA0.12 mg/mL BenzamidearomaticAmides

0.302

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.354

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.423

H2O24 mM hydrogen peroxideDNAdamaging

-0.307

Levo10 ug/mL LevofloxacinDNAdamaging

-0.283

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.336

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.295

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.264

UVUV-irradiationDNAdamaging

0.498

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.631

Antimycin12.5-50 ug/mL Antimycin A?

-0.408

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-1.286

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.920

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.586

PA8240.2-2 ug/mL PA-824?

1.194

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.312

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.279

Verapamil50 uM Verapamil?

-0.555

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.177

methoxatin10-20 ug/mL Methoxatin?