from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3484/cpsA

LFCtreatmentdescriptionclass of inhibitor

-0.244

Amikacinug/mL Amikacintranslation

0.991

Cap5-10ug/mL Capreomycintranslation

0.199

Rox10-50 ug/mL Roxithromycintranslation

-0.015

SM2-5 ug/mL Streptomycintranslation

0.671

Tet5-10 ug/mL Tetracyclinetranslation

0.041

Rif0.2-5ug/mL Rifampicintranscription

0.173

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.462

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.053

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.632

CPZ10-50 ug/mL Chlorpromazinerespiration

1.762

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.822

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.354

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.578

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.372

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.276

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.778

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.084

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.261

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.372

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.650

KCN5-20 ug/mL Potassium cyaniderespiration

0.182

NaN30.2-2 mM Sodium aziderespiration

1.007

Nigericin50 uM Nigericinrespiration

0.079

TRC10-150 ug/mL Triclosanrespiration

-0.324

TRZ10-25 ug/mL Thioridazinerespiration

0.660

Valinomycin0.5-10 uM Valinomycinrespiration

-0.684

ZnSO42 mM ZnSO4respiration

0.081

menadione6-10 ug/mL Menadionerespiration

0.797

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-1.022

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.317

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.275

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

2.203

NRP_1Non-replicating persistence stage 1dosRassociated

-0.342

Amp0.2mg/mL AmpicillincellWall

-0.610

Cephalexin20-100 ug/mL CephalexincellWall

0.641

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.016

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.385

EMB10-20 ug/mL EthambutolcellWall

-0.172

Eta12-40 ug/mL EthionamidecellWall

-0.484

INH0.2-0.4 ug/mL IsoniazidcellWall

0.707

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.059

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-2.190

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.607

BZA0.12 mg/mL BenzamidearomaticAmides

0.275

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.778

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.604

H2O24 mM hydrogen peroxideDNAdamaging

-0.814

Levo10 ug/mL LevofloxacinDNAdamaging

0.620

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.826

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.029

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.446

UVUV-irradiationDNAdamaging

0.231

ARP41-4 ug/mL Antitubercular compound ARP4?

0.239

Antimycin12.5-50 ug/mL Antimycin A?

-0.154

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.023

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.275

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.637

PA8240.2-2 ug/mL PA-824?

0.534

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.532

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.535

Verapamil50 uM Verapamil?

-0.172

mercaptoethanol2 mM 2-Mercaptoethanol?

1.216

methoxatin10-20 ug/mL Methoxatin?