from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3420c/rimI

LFCtreatmentdescriptionclass of inhibitor

0.916

Amikacinug/mL Amikacintranslation

-0.192

Cap5-10ug/mL Capreomycintranslation

0.035

Rox10-50 ug/mL Roxithromycintranslation

0.878

SM2-5 ug/mL Streptomycintranslation

-0.685

Tet5-10 ug/mL Tetracyclinetranslation

-1.459

Rif0.2-5ug/mL Rifampicintranscription

-1.797

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.351

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.401

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.648

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.194

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.261

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.725

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.738

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.583

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.504

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.688

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.647

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.556

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.034

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

2.251

KCN5-20 ug/mL Potassium cyaniderespiration

-0.245

NaN30.2-2 mM Sodium aziderespiration

-0.686

Nigericin50 uM Nigericinrespiration

-0.941

TRC10-150 ug/mL Triclosanrespiration

-0.496

TRZ10-25 ug/mL Thioridazinerespiration

1.780

Valinomycin0.5-10 uM Valinomycinrespiration

-1.327

ZnSO42 mM ZnSO4respiration

-0.218

menadione6-10 ug/mL Menadionerespiration

-0.497

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.340

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.390

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.379

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.041

NRP_1Non-replicating persistence stage 1dosRassociated

-0.168

Amp0.2mg/mL AmpicillincellWall

-0.446

Cephalexin20-100 ug/mL CephalexincellWall

0.157

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.740

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.574

EMB10-20 ug/mL EthambutolcellWall

-0.033

Eta12-40 ug/mL EthionamidecellWall

0.321

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.345

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.385

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.397

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.110

BZA0.12 mg/mL BenzamidearomaticAmides

1.240

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.391

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.345

H2O24 mM hydrogen peroxideDNAdamaging

-0.274

Levo10 ug/mL LevofloxacinDNAdamaging

0.275

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.305

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.184

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.586

UVUV-irradiationDNAdamaging

-0.602

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.461

Antimycin12.5-50 ug/mL Antimycin A?

-0.358

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.219

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.560

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.613

PA8240.2-2 ug/mL PA-824?

1.527

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.416

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.491

Verapamil50 uM Verapamil?

-0.451

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.429

methoxatin10-20 ug/mL Methoxatin?