from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3392c/cmaA1

LFCtreatmentdescriptionclass of inhibitor

0.432

Amikacinug/mL Amikacintranslation

1.443

Cap5-10ug/mL Capreomycintranslation

0.686

Rox10-50 ug/mL Roxithromycintranslation

1.065

SM2-5 ug/mL Streptomycintranslation

0.169

Tet5-10 ug/mL Tetracyclinetranslation

-1.203

Rif0.2-5ug/mL Rifampicintranscription

0.304

Rifp0.1-0.5ug/mL Rifapentinetranscription

-2.182

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.553

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.768

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.377

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.233

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.471

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.249

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.089

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.121

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.519

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.578

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.034

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.196

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.569

KCN5-20 ug/mL Potassium cyaniderespiration

0.982

NaN30.2-2 mM Sodium aziderespiration

1.572

Nigericin50 uM Nigericinrespiration

-1.187

TRC10-150 ug/mL Triclosanrespiration

-0.202

TRZ10-25 ug/mL Thioridazinerespiration

0.497

Valinomycin0.5-10 uM Valinomycinrespiration

-1.601

ZnSO42 mM ZnSO4respiration

0.557

menadione6-10 ug/mL Menadionerespiration

0.312

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.421

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.198

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.823

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.672

NRP_1Non-replicating persistence stage 1dosRassociated

0.452

Amp0.2mg/mL AmpicillincellWall

0.409

Cephalexin20-100 ug/mL CephalexincellWall

0.884

Cerulenin0.32-5 ug/mL CerulenincellWall

0.264

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.097

EMB10-20 ug/mL EthambutolcellWall

0.316

Eta12-40 ug/mL EthionamidecellWall

0.371

INH0.2-0.4 ug/mL IsoniazidcellWall

0.133

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.586

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.052

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.483

BZA0.12 mg/mL BenzamidearomaticAmides

-1.031

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-1.202

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.193

H2O24 mM hydrogen peroxideDNAdamaging

0.059

Levo10 ug/mL LevofloxacinDNAdamaging

0.704

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.044

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.009

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.567

UVUV-irradiationDNAdamaging

-1.070

ARP41-4 ug/mL Antitubercular compound ARP4?

0.212

Antimycin12.5-50 ug/mL Antimycin A?

0.613

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.467

PA_110-50 ug/mL Antitubercular compound PA-1?

0.696

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.095

PA8240.2-2 ug/mL PA-824?

-0.126

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.090

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.293

Verapamil50 uM Verapamil?

0.811

mercaptoethanol2 mM 2-Mercaptoethanol?

0.707

methoxatin10-20 ug/mL Methoxatin?