from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3331/sugI

LFCtreatmentdescriptionclass of inhibitor

1.322

Amikacinug/mL Amikacintranslation

1.308

Cap5-10ug/mL Capreomycintranslation

3.584

Rox10-50 ug/mL Roxithromycintranslation

0.324

SM2-5 ug/mL Streptomycintranslation

1.598

Tet5-10 ug/mL Tetracyclinetranslation

0.312

Rif0.2-5ug/mL Rifampicintranscription

0.895

Rifp0.1-0.5ug/mL Rifapentinetranscription

2.986

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.069

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.535

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.082

Clofazimine10-13 ug/mL Clofaziminerespiration

0.187

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.747

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.309

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.350

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.048

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.481

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.712

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.345

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.639

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.073

KCN5-20 ug/mL Potassium cyaniderespiration

-0.417

NaN30.2-2 mM Sodium aziderespiration

0.430

Nigericin50 uM Nigericinrespiration

-0.337

TRC10-150 ug/mL Triclosanrespiration

0.921

TRZ10-25 ug/mL Thioridazinerespiration

0.433

Valinomycin0.5-10 uM Valinomycinrespiration

0.123

ZnSO42 mM ZnSO4respiration

0.158

menadione6-10 ug/mL Menadionerespiration

0.078

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.135

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.231

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.039

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.136

NRP_1Non-replicating persistence stage 1dosRassociated

-0.173

Amp0.2mg/mL AmpicillincellWall

0.151

Cephalexin20-100 ug/mL CephalexincellWall

0.413

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.080

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.578

EMB10-20 ug/mL EthambutolcellWall

0.100

Eta12-40 ug/mL EthionamidecellWall

0.003

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.132

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.797

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.005

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.546

BZA0.12 mg/mL BenzamidearomaticAmides

-0.546

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.355

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.476

H2O24 mM hydrogen peroxideDNAdamaging

0.434

Levo10 ug/mL LevofloxacinDNAdamaging

-1.134

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.430

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.065

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.652

UVUV-irradiationDNAdamaging

1.849

ARP41-4 ug/mL Antitubercular compound ARP4?

0.030

Antimycin12.5-50 ug/mL Antimycin A?

0.317

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.752

PA_110-50 ug/mL Antitubercular compound PA-1?

-1.325

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.088

PA8240.2-2 ug/mL PA-824?

-0.274

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.408

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.342

Verapamil50 uM Verapamil?

0.547

mercaptoethanol2 mM 2-Mercaptoethanol?

0.373

methoxatin10-20 ug/mL Methoxatin?