from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3323c/moaX

LFCtreatmentdescriptionclass of inhibitor

0.572

Amikacinug/mL Amikacintranslation

-0.553

Cap5-10ug/mL Capreomycintranslation

0.242

Rox10-50 ug/mL Roxithromycintranslation

0.013

SM2-5 ug/mL Streptomycintranslation

0.066

Tet5-10 ug/mL Tetracyclinetranslation

1.065

Rif0.2-5ug/mL Rifampicintranscription

0.140

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.065

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.648

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.551

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.065

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.128

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.668

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.372

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.481

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.294

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.141

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.294

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.718

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.442

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.377

Nigericin50 uM Nigericinrespiration

0.476

TRC10-150 ug/mL Triclosanrespiration

0.806

TRZ10-25 ug/mL Thioridazinerespiration

-0.991

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.369

menadione6-10 ug/mL Menadionerespiration

-0.498

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.678

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.067

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.690

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.290

NRP_1Non-replicating persistence stage 1dosRassociated

0.540

Amp0.2mg/mL AmpicillincellWall

-0.362

Cephalexin20-100 ug/mL CephalexincellWall

0.026

Cerulenin0.32-5 ug/mL CerulenincellWall

0.321

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.164

EMB10-20 ug/mL EthambutolcellWall

1.412

Eta12-40 ug/mL EthionamidecellWall

0.376

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.501

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.025

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.973

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.523

BZA0.12 mg/mL BenzamidearomaticAmides

0.159

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.037

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.467

H2O24 mM hydrogen peroxideDNAdamaging

-0.313

Levo10 ug/mL LevofloxacinDNAdamaging

0.123

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.130

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.882

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.190

UVUV-irradiationDNAdamaging

0.299

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.489

Antimycin12.5-50 ug/mL Antimycin A?

-1.066

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.082

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.586

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.180

PA8240.2-2 ug/mL PA-824?

-1.038

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.274

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.897

Verapamil50 uM Verapamil?

-0.665

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.405

methoxatin10-20 ug/mL Methoxatin?