from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3306c/amiB1

LFCtreatmentdescriptionclass of inhibitor

-1.246

Amikacinug/mL Amikacintranslation

-0.792

Cap5-10ug/mL Capreomycintranslation

-1.066

Rox10-50 ug/mL Roxithromycintranslation

-0.867

SM2-5 ug/mL Streptomycintranslation

-0.579

Tet5-10 ug/mL Tetracyclinetranslation

1.099

Rif0.2-5ug/mL Rifampicintranscription

-0.206

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.955

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.170

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.005

CPZ10-50 ug/mL Chlorpromazinerespiration

0.043

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.351

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.903

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.402

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

2.620

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.378

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.365

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.042

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.969

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.643

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

2.578

KCN5-20 ug/mL Potassium cyaniderespiration

0.178

NaN30.2-2 mM Sodium aziderespiration

0.617

Nigericin50 uM Nigericinrespiration

0.269

TRC10-150 ug/mL Triclosanrespiration

-0.224

TRZ10-25 ug/mL Thioridazinerespiration

0.251

Valinomycin0.5-10 uM Valinomycinrespiration

-1.488

ZnSO42 mM ZnSO4respiration

1.216

menadione6-10 ug/mL Menadionerespiration

-0.286

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.383

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.459

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.032

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.308

NRP_1Non-replicating persistence stage 1dosRassociated

0.049

Amp0.2mg/mL AmpicillincellWall

-0.404

Cephalexin20-100 ug/mL CephalexincellWall

-0.189

Cerulenin0.32-5 ug/mL CerulenincellWall

0.371

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.063

EMB10-20 ug/mL EthambutolcellWall

-1.433

Eta12-40 ug/mL EthionamidecellWall

-1.652

INH0.2-0.4 ug/mL IsoniazidcellWall

0.215

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.037

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.860

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.346

BZA0.12 mg/mL BenzamidearomaticAmides

-0.066

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.664

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.181

H2O24 mM hydrogen peroxideDNAdamaging

-0.665

Levo10 ug/mL LevofloxacinDNAdamaging

-0.014

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.927

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.550

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.087

UVUV-irradiationDNAdamaging

0.736

ARP41-4 ug/mL Antitubercular compound ARP4?

0.063

Antimycin12.5-50 ug/mL Antimycin A?

0.668

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.705

PA_110-50 ug/mL Antitubercular compound PA-1?

0.442

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.881

PA8240.2-2 ug/mL PA-824?

0.958

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.217

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.123

Verapamil50 uM Verapamil?

0.497

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.188

methoxatin10-20 ug/mL Methoxatin?