from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3271c/-

LFCtreatmentdescriptionclass of inhibitor

0.494

Amikacinug/mL Amikacintranslation

0.071

Cap5-10ug/mL Capreomycintranslation

0.585

Rox10-50 ug/mL Roxithromycintranslation

-0.037

SM2-5 ug/mL Streptomycintranslation

1.283

Tet5-10 ug/mL Tetracyclinetranslation

0.285

Rif0.2-5ug/mL Rifampicintranscription

-0.338

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.581

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.637

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.227

CPZ10-50 ug/mL Chlorpromazinerespiration

-1.262

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.252

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.437

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.064

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.655

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.521

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.407

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.194

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.569

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.868

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.929

KCN5-20 ug/mL Potassium cyaniderespiration

-0.111

NaN30.2-2 mM Sodium aziderespiration

-0.207

Nigericin50 uM Nigericinrespiration

0.133

TRC10-150 ug/mL Triclosanrespiration

-0.694

TRZ10-25 ug/mL Thioridazinerespiration

-2.448

Valinomycin0.5-10 uM Valinomycinrespiration

2.298

ZnSO42 mM ZnSO4respiration

0.087

menadione6-10 ug/mL Menadionerespiration

-0.282

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.350

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.012

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.231

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.176

NRP_1Non-replicating persistence stage 1dosRassociated

0.374

Amp0.2mg/mL AmpicillincellWall

0.262

Cephalexin20-100 ug/mL CephalexincellWall

0.157

Cerulenin0.32-5 ug/mL CerulenincellWall

0.124

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.060

EMB10-20 ug/mL EthambutolcellWall

0.621

Eta12-40 ug/mL EthionamidecellWall

0.693

INH0.2-0.4 ug/mL IsoniazidcellWall

0.526

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.665

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.294

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.448

BZA0.12 mg/mL BenzamidearomaticAmides

0.497

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.119

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.028

H2O24 mM hydrogen peroxideDNAdamaging

0.467

Levo10 ug/mL LevofloxacinDNAdamaging

0.128

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

1.606

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.963

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.521

UVUV-irradiationDNAdamaging

-1.484

ARP41-4 ug/mL Antitubercular compound ARP4?

0.165

Antimycin12.5-50 ug/mL Antimycin A?

-0.637

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.295

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.131

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.940

PA8240.2-2 ug/mL PA-824?

0.229

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.143

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.478

Verapamil50 uM Verapamil?

-0.386

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.228

methoxatin10-20 ug/mL Methoxatin?