from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3229c/desA3

LFCtreatmentdescriptionclass of inhibitor

1.492

Amikacinug/mL Amikacintranslation

1.607

Cap5-10ug/mL Capreomycintranslation

1.405

Rox10-50 ug/mL Roxithromycintranslation

0.809

SM2-5 ug/mL Streptomycintranslation

0.194

Tet5-10 ug/mL Tetracyclinetranslation

0.188

Rif0.2-5ug/mL Rifampicintranscription

0.121

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.323

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-2.018

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-1.087

CPZ10-50 ug/mL Chlorpromazinerespiration

1.345

Clofazimine10-13 ug/mL Clofaziminerespiration

0.011

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.203

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.525

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.445

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.007

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.232

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.934

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.646

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.824

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.067

KCN5-20 ug/mL Potassium cyaniderespiration

-0.666

NaN30.2-2 mM Sodium aziderespiration

-0.549

Nigericin50 uM Nigericinrespiration

-0.665

TRC10-150 ug/mL Triclosanrespiration

-0.310

TRZ10-25 ug/mL Thioridazinerespiration

1.350

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.852

menadione6-10 ug/mL Menadionerespiration

0.606

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.039

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.340

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.003

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.165

NRP_1Non-replicating persistence stage 1dosRassociated

0.226

Amp0.2mg/mL AmpicillincellWall

0.193

Cephalexin20-100 ug/mL CephalexincellWall

-1.072

Cerulenin0.32-5 ug/mL CerulenincellWall

0.090

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.374

EMB10-20 ug/mL EthambutolcellWall

0.305

Eta12-40 ug/mL EthionamidecellWall

0.600

INH0.2-0.4 ug/mL IsoniazidcellWall

0.015

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.073

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.767

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.200

BZA0.12 mg/mL BenzamidearomaticAmides

0.536

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.296

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.343

H2O24 mM hydrogen peroxideDNAdamaging

0.085

Levo10 ug/mL LevofloxacinDNAdamaging

-0.295

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.295

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.355

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.367

UVUV-irradiationDNAdamaging

0.143

ARP41-4 ug/mL Antitubercular compound ARP4?

0.668

Antimycin12.5-50 ug/mL Antimycin A?

-0.054

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.370

PA_110-50 ug/mL Antitubercular compound PA-1?

0.568

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.584

PA8240.2-2 ug/mL PA-824?

1.684

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.803

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-1.557

Verapamil50 uM Verapamil?

-0.346

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.460

methoxatin10-20 ug/mL Methoxatin?