from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3215/entC

LFCtreatmentdescriptionclass of inhibitor

-1.451

Amikacinug/mL Amikacintranslation

-1.298

Cap5-10ug/mL Capreomycintranslation

-1.881

Rox10-50 ug/mL Roxithromycintranslation

-0.569

SM2-5 ug/mL Streptomycintranslation

-0.323

Tet5-10 ug/mL Tetracyclinetranslation

0.466

Rif0.2-5ug/mL Rifampicintranscription

0.494

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.109

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.534

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.331

CPZ10-50 ug/mL Chlorpromazinerespiration

0.290

Clofazimine10-13 ug/mL Clofaziminerespiration

0.985

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.565

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.790

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.694

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

1.046

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.679

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.027

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.062

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.538

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.287

KCN5-20 ug/mL Potassium cyaniderespiration

1.335

NaN30.2-2 mM Sodium aziderespiration

0.758

Nigericin50 uM Nigericinrespiration

-0.495

TRC10-150 ug/mL Triclosanrespiration

-0.665

TRZ10-25 ug/mL Thioridazinerespiration

-1.507

Valinomycin0.5-10 uM Valinomycinrespiration

1.688

ZnSO42 mM ZnSO4respiration

-0.062

menadione6-10 ug/mL Menadionerespiration

0.042

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.622

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.632

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.043

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.642

NRP_1Non-replicating persistence stage 1dosRassociated

0.091

Amp0.2mg/mL AmpicillincellWall

0.482

Cephalexin20-100 ug/mL CephalexincellWall

0.836

Cerulenin0.32-5 ug/mL CerulenincellWall

0.406

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.278

EMB10-20 ug/mL EthambutolcellWall

0.984

Eta12-40 ug/mL EthionamidecellWall

1.201

INH0.2-0.4 ug/mL IsoniazidcellWall

0.655

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.647

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.199

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.766

BZA0.12 mg/mL BenzamidearomaticAmides

-0.548

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.742

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.145

H2O24 mM hydrogen peroxideDNAdamaging

0.018

Levo10 ug/mL LevofloxacinDNAdamaging

0.457

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.013

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.009

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.010

UVUV-irradiationDNAdamaging

-1.335

ARP41-4 ug/mL Antitubercular compound ARP4?

0.877

Antimycin12.5-50 ug/mL Antimycin A?

0.948

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

1.021

PA_110-50 ug/mL Antitubercular compound PA-1?

1.141

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.965

PA8240.2-2 ug/mL PA-824?

-0.872

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.312

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.429

Verapamil50 uM Verapamil?

0.358

mercaptoethanol2 mM 2-Mercaptoethanol?

0.832

methoxatin10-20 ug/mL Methoxatin?