from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3207c/-

LFCtreatmentdescriptionclass of inhibitor

0.428

Amikacinug/mL Amikacintranslation

0.245

Cap5-10ug/mL Capreomycintranslation

-1.868

Rox10-50 ug/mL Roxithromycintranslation

0.384

SM2-5 ug/mL Streptomycintranslation

-0.317

Tet5-10 ug/mL Tetracyclinetranslation

0.035

Rif0.2-5ug/mL Rifampicintranscription

0.693

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.278

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.558

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.596

CPZ10-50 ug/mL Chlorpromazinerespiration

0.350

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.109

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.073

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.794

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.499

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.057

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.581

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.922

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.152

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.533

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.423

KCN5-20 ug/mL Potassium cyaniderespiration

-0.103

NaN30.2-2 mM Sodium aziderespiration

-0.532

Nigericin50 uM Nigericinrespiration

-0.279

TRC10-150 ug/mL Triclosanrespiration

0.633

TRZ10-25 ug/mL Thioridazinerespiration

-1.020

Valinomycin0.5-10 uM Valinomycinrespiration

1.344

ZnSO42 mM ZnSO4respiration

-0.221

menadione6-10 ug/mL Menadionerespiration

-0.155

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.034

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.337

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.190

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.235

NRP_1Non-replicating persistence stage 1dosRassociated

1.291

Amp0.2mg/mL AmpicillincellWall

0.511

Cephalexin20-100 ug/mL CephalexincellWall

-0.313

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.184

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.513

EMB10-20 ug/mL EthambutolcellWall

0.872

Eta12-40 ug/mL EthionamidecellWall

0.981

INH0.2-0.4 ug/mL IsoniazidcellWall

0.507

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.378

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.402

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.108

BZA0.12 mg/mL BenzamidearomaticAmides

-1.321

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.972

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.294

H2O24 mM hydrogen peroxideDNAdamaging

-0.339

Levo10 ug/mL LevofloxacinDNAdamaging

-0.259

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.200

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.198

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.004

UVUV-irradiationDNAdamaging

-0.115

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.681

Antimycin12.5-50 ug/mL Antimycin A?

-0.096

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.660

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.293

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.693

PA8240.2-2 ug/mL PA-824?

0.576

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.029

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.228

Verapamil50 uM Verapamil?

-0.358

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.064

methoxatin10-20 ug/mL Methoxatin?