from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3203/lipV

LFCtreatmentdescriptionclass of inhibitor

0.101

Amikacinug/mL Amikacintranslation

0.008

Cap5-10ug/mL Capreomycintranslation

0.232

Rox10-50 ug/mL Roxithromycintranslation

0.582

SM2-5 ug/mL Streptomycintranslation

0.411

Tet5-10 ug/mL Tetracyclinetranslation

1.208

Rif0.2-5ug/mL Rifampicintranscription

-0.098

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.912

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.492

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.151

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.035

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.321

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.525

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.134

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.466

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.391

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.123

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.139

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.316

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.091

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.952

KCN5-20 ug/mL Potassium cyaniderespiration

-1.381

NaN30.2-2 mM Sodium aziderespiration

0.295

Nigericin50 uM Nigericinrespiration

0.550

TRC10-150 ug/mL Triclosanrespiration

0.624

TRZ10-25 ug/mL Thioridazinerespiration

0.268

Valinomycin0.5-10 uM Valinomycinrespiration

0.297

ZnSO42 mM ZnSO4respiration

0.707

menadione6-10 ug/mL Menadionerespiration

0.232

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.247

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.131

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.306

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.967

NRP_1Non-replicating persistence stage 1dosRassociated

0.073

Amp0.2mg/mL AmpicillincellWall

-0.289

Cephalexin20-100 ug/mL CephalexincellWall

-0.573

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.317

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.360

EMB10-20 ug/mL EthambutolcellWall

0.112

Eta12-40 ug/mL EthionamidecellWall

0.173

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.633

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.229

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.432

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.018

BZA0.12 mg/mL BenzamidearomaticAmides

-0.543

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.109

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.104

H2O24 mM hydrogen peroxideDNAdamaging

0.588

Levo10 ug/mL LevofloxacinDNAdamaging

-0.761

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.691

Novobiocin10 ug/mL NovobiocinDNAdamaging

1.593

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.036

UVUV-irradiationDNAdamaging

-0.539

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.297

Antimycin12.5-50 ug/mL Antimycin A?

-0.307

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.295

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.584

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.235

PA8240.2-2 ug/mL PA-824?

0.256

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.051

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.136

Verapamil50 uM Verapamil?

-0.284

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.679

methoxatin10-20 ug/mL Methoxatin?