from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3201c/-

LFCtreatmentdescriptionclass of inhibitor

-0.193

Amikacinug/mL Amikacintranslation

-0.945

Cap5-10ug/mL Capreomycintranslation

-0.774

Rox10-50 ug/mL Roxithromycintranslation

-0.430

SM2-5 ug/mL Streptomycintranslation

0.153

Tet5-10 ug/mL Tetracyclinetranslation

0.570

Rif0.2-5ug/mL Rifampicintranscription

0.513

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.989

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.156

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.032

CPZ10-50 ug/mL Chlorpromazinerespiration

1.357

Clofazimine10-13 ug/mL Clofaziminerespiration

0.086

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.607

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.038

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.962

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.010

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.221

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.436

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.753

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.400

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.665

KCN5-20 ug/mL Potassium cyaniderespiration

0.278

NaN30.2-2 mM Sodium aziderespiration

-0.506

Nigericin50 uM Nigericinrespiration

0.788

TRC10-150 ug/mL Triclosanrespiration

1.378

TRZ10-25 ug/mL Thioridazinerespiration

-0.076

Valinomycin0.5-10 uM Valinomycinrespiration

-1.156

ZnSO42 mM ZnSO4respiration

0.328

menadione6-10 ug/mL Menadionerespiration

0.176

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.723

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.131

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.432

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.816

NRP_1Non-replicating persistence stage 1dosRassociated

-0.617

Amp0.2mg/mL AmpicillincellWall

-0.090

Cephalexin20-100 ug/mL CephalexincellWall

-0.337

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.932

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.636

EMB10-20 ug/mL EthambutolcellWall

-0.033

Eta12-40 ug/mL EthionamidecellWall

0.151

INH0.2-0.4 ug/mL IsoniazidcellWall

0.331

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.775

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.136

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.352

BZA0.12 mg/mL BenzamidearomaticAmides

-0.663

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.266

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.058

H2O24 mM hydrogen peroxideDNAdamaging

0.621

Levo10 ug/mL LevofloxacinDNAdamaging

-0.581

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.777

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.470

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.594

UVUV-irradiationDNAdamaging

2.852

ARP41-4 ug/mL Antitubercular compound ARP4?

0.132

Antimycin12.5-50 ug/mL Antimycin A?

0.011

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.051

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.153

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.678

PA8240.2-2 ug/mL PA-824?

0.964

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.854

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.110

Verapamil50 uM Verapamil?

0.267

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.525

methoxatin10-20 ug/mL Methoxatin?