from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3161c/-

LFCtreatmentdescriptionclass of inhibitor

-0.477

Amikacinug/mL Amikacintranslation

-0.664

Cap5-10ug/mL Capreomycintranslation

-0.495

Rox10-50 ug/mL Roxithromycintranslation

-0.364

SM2-5 ug/mL Streptomycintranslation

-0.598

Tet5-10 ug/mL Tetracyclinetranslation

-0.249

Rif0.2-5ug/mL Rifampicintranscription

-0.591

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.797

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.179

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.359

CPZ10-50 ug/mL Chlorpromazinerespiration

1.535

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.558

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.767

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.240

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.142

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.434

Econazole10-24 ug/mL Econazole (azole drug)respiration

1.931

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.680

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.670

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.324

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.116

KCN5-20 ug/mL Potassium cyaniderespiration

-0.598

NaN30.2-2 mM Sodium aziderespiration

-0.767

Nigericin50 uM Nigericinrespiration

2.388

TRC10-150 ug/mL Triclosanrespiration

2.381

TRZ10-25 ug/mL Thioridazinerespiration

0.064

Valinomycin0.5-10 uM Valinomycinrespiration

-0.728

ZnSO42 mM ZnSO4respiration

-0.392

menadione6-10 ug/mL Menadionerespiration

0.351

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.550

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.340

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.838

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.325

NRP_1Non-replicating persistence stage 1dosRassociated

-0.560

Amp0.2mg/mL AmpicillincellWall

-0.531

Cephalexin20-100 ug/mL CephalexincellWall

-0.575

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.451

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.548

EMB10-20 ug/mL EthambutolcellWall

-0.572

Eta12-40 ug/mL EthionamidecellWall

-0.607

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.400

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.023

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.135

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.024

BZA0.12 mg/mL BenzamidearomaticAmides

-0.399

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.198

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.468

H2O24 mM hydrogen peroxideDNAdamaging

-0.638

Levo10 ug/mL LevofloxacinDNAdamaging

-0.646

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.439

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.463

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.474

UVUV-irradiationDNAdamaging

-0.005

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.536

Antimycin12.5-50 ug/mL Antimycin A?

-0.680

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.409

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.607

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.356

PA8240.2-2 ug/mL PA-824?

0.005

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.174

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

2.084

Verapamil50 uM Verapamil?

-0.550

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.663

methoxatin10-20 ug/mL Methoxatin?