from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3132c/devS

LFCtreatmentdescriptionclass of inhibitor

-0.883

Amikacinug/mL Amikacintranslation

-0.366

Cap5-10ug/mL Capreomycintranslation

-1.119

Rox10-50 ug/mL Roxithromycintranslation

1.880

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

0.158

Rif0.2-5ug/mL Rifampicintranscription

-0.523

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.285

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.052

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.383

CPZ10-50 ug/mL Chlorpromazinerespiration

0.639

Clofazimine10-13 ug/mL Clofaziminerespiration

1.207

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.135

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.034

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.798

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.149

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.189

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.343

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.024

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.813

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.113

Nigericin50 uM Nigericinrespiration

0.174

TRC10-150 ug/mL Triclosanrespiration

-0.213

TRZ10-25 ug/mL Thioridazinerespiration

-0.963

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.691

menadione6-10 ug/mL Menadionerespiration

-0.117

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-1.333

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.654

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.947

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.270

NRP_1Non-replicating persistence stage 1dosRassociated

0.012

Amp0.2mg/mL AmpicillincellWall

0.566

Cephalexin20-100 ug/mL CephalexincellWall

-0.320

Cerulenin0.32-5 ug/mL CerulenincellWall

0.275

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.199

EMB10-20 ug/mL EthambutolcellWall

0.054

Eta12-40 ug/mL EthionamidecellWall

-0.141

INH0.2-0.4 ug/mL IsoniazidcellWall

0.485

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.324

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.633

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.982

BZA0.12 mg/mL BenzamidearomaticAmides

0.007

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.669

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.054

H2O24 mM hydrogen peroxideDNAdamaging

-0.184

Levo10 ug/mL LevofloxacinDNAdamaging

0.234

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.126

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.638

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.153

UVUV-irradiationDNAdamaging

0.783

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.213

Antimycin12.5-50 ug/mL Antimycin A?

-1.563

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.314

PA_110-50 ug/mL Antitubercular compound PA-1?

0.057

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.327

PA8240.2-2 ug/mL PA-824?

2.736

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.218

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.311

Verapamil50 uM Verapamil?

-1.814

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.112

methoxatin10-20 ug/mL Methoxatin?