from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3124/moaR1

LFCtreatmentdescriptionclass of inhibitor

-0.217

Amikacinug/mL Amikacintranslation

1.047

Cap5-10ug/mL Capreomycintranslation

-0.060

Rox10-50 ug/mL Roxithromycintranslation

-1.737

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

0.631

Rif0.2-5ug/mL Rifampicintranscription

0.306

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.129

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.379

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.423

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.026

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.863

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.000

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.347

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.436

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.029

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-1.785

Nigericin50 uM Nigericinrespiration

0.168

TRC10-150 ug/mL Triclosanrespiration

-0.510

TRZ10-25 ug/mL Thioridazinerespiration

-0.807

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-1.770

menadione6-10 ug/mL Menadionerespiration

-0.496

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.075

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

1.256

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.178

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.532

NRP_1Non-replicating persistence stage 1dosRassociated

-1.008

Amp0.2mg/mL AmpicillincellWall

-0.050

Cephalexin20-100 ug/mL CephalexincellWall

0.720

Cerulenin0.32-5 ug/mL CerulenincellWall

0.204

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.029

EMB10-20 ug/mL EthambutolcellWall

-0.633

Eta12-40 ug/mL EthionamidecellWall

0.288

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.611

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.601

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.172

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.006

BZA0.12 mg/mL BenzamidearomaticAmides

-0.058

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.215

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.610

H2O24 mM hydrogen peroxideDNAdamaging

-0.061

Levo10 ug/mL LevofloxacinDNAdamaging

-0.183

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.078

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.563

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.061

UVUV-irradiationDNAdamaging

0.324

ARP41-4 ug/mL Antitubercular compound ARP4?

0.167

Antimycin12.5-50 ug/mL Antimycin A?

-1.436

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.433

PA_110-50 ug/mL Antitubercular compound PA-1?

0.145

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.430

PA8240.2-2 ug/mL PA-824?

-0.371

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.012

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

-1.695

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.211

methoxatin10-20 ug/mL Methoxatin?