from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3112/moaD1

LFCtreatmentdescriptionclass of inhibitor

-0.324

Amikacinug/mL Amikacintranslation

0.417

Cap5-10ug/mL Capreomycintranslation

-0.929

Rox10-50 ug/mL Roxithromycintranslation

0.993

SM2-5 ug/mL Streptomycintranslation

0.000

Tet5-10 ug/mL Tetracyclinetranslation

-0.092

Rif0.2-5ug/mL Rifampicintranscription

0.085

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.256

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.561

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.000

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.848

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.352

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.000

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.830

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.522

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.235

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.104

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.333

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

0.200

Nigericin50 uM Nigericinrespiration

0.058

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

-0.040

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.328

menadione6-10 ug/mL Menadionerespiration

-0.278

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.490

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.150

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.928

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.236

NRP_1Non-replicating persistence stage 1dosRassociated

-0.897

Amp0.2mg/mL AmpicillincellWall

-0.462

Cephalexin20-100 ug/mL CephalexincellWall

0.374

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.195

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.003

EMB10-20 ug/mL EthambutolcellWall

0.468

Eta12-40 ug/mL EthionamidecellWall

0.023

INH0.2-0.4 ug/mL IsoniazidcellWall

-1.254

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

BZA0.12 mg/mL BenzamidearomaticAmides

1.379

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.085

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.611

H2O24 mM hydrogen peroxideDNAdamaging

-0.661

Levo10 ug/mL LevofloxacinDNAdamaging

0.791

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.604

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.109

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

1.086

Antimycin12.5-50 ug/mL Antimycin A?

-0.779

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.882

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.822

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.485

PA8240.2-2 ug/mL PA-824?

0.505

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.303

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.085

Verapamil50 uM Verapamil?

0.221

mercaptoethanol2 mM 2-Mercaptoethanol?

0.816

methoxatin10-20 ug/mL Methoxatin?