from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3102c/ftsE

LFCtreatmentdescriptionclass of inhibitor

0.284

Amikacinug/mL Amikacintranslation

0.784

Cap5-10ug/mL Capreomycintranslation

2.122

Rox10-50 ug/mL Roxithromycintranslation

0.591

SM2-5 ug/mL Streptomycintranslation

0.866

Tet5-10 ug/mL Tetracyclinetranslation

0.993

Rif0.2-5ug/mL Rifampicintranscription

0.129

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.531

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.131

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.105

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.712

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.263

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.807

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.097

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.075

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.333

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.938

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.697

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-2.282

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.710

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-2.319

KCN5-20 ug/mL Potassium cyaniderespiration

-1.196

NaN30.2-2 mM Sodium aziderespiration

1.871

Nigericin50 uM Nigericinrespiration

-0.369

TRC10-150 ug/mL Triclosanrespiration

-1.216

TRZ10-25 ug/mL Thioridazinerespiration

-0.244

Valinomycin0.5-10 uM Valinomycinrespiration

0.426

ZnSO42 mM ZnSO4respiration

0.686

menadione6-10 ug/mL Menadionerespiration

0.418

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.571

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.215

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.189

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.266

NRP_1Non-replicating persistence stage 1dosRassociated

0.112

Amp0.2mg/mL AmpicillincellWall

0.176

Cephalexin20-100 ug/mL CephalexincellWall

0.774

Cerulenin0.32-5 ug/mL CerulenincellWall

0.180

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.243

EMB10-20 ug/mL EthambutolcellWall

0.237

Eta12-40 ug/mL EthionamidecellWall

-0.212

INH0.2-0.4 ug/mL IsoniazidcellWall

0.492

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.026

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.135

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.264

BZA0.12 mg/mL BenzamidearomaticAmides

0.167

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.128

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.890

H2O24 mM hydrogen peroxideDNAdamaging

-0.075

Levo10 ug/mL LevofloxacinDNAdamaging

0.625

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.501

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.262

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.487

UVUV-irradiationDNAdamaging

-0.189

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.179

Antimycin12.5-50 ug/mL Antimycin A?

0.641

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.260

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.594

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.534

PA8240.2-2 ug/mL PA-824?

-1.200

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.041

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.492

Verapamil50 uM Verapamil?

0.034

mercaptoethanol2 mM 2-Mercaptoethanol?

0.149

methoxatin10-20 ug/mL Methoxatin?