from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3101c/ftsX

LFCtreatmentdescriptionclass of inhibitor

-0.501

Amikacinug/mL Amikacintranslation

1.000

Cap5-10ug/mL Capreomycintranslation

1.089

Rox10-50 ug/mL Roxithromycintranslation

1.406

SM2-5 ug/mL Streptomycintranslation

-0.867

Tet5-10 ug/mL Tetracyclinetranslation

-1.683

Rif0.2-5ug/mL Rifampicintranscription

0.457

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.473

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.343

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.328

CPZ10-50 ug/mL Chlorpromazinerespiration

0.352

Clofazimine10-13 ug/mL Clofaziminerespiration

0.713

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.497

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.904

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.448

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.494

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.316

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.038

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.199

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.347

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.650

KCN5-20 ug/mL Potassium cyaniderespiration

-1.071

NaN30.2-2 mM Sodium aziderespiration

0.708

Nigericin50 uM Nigericinrespiration

-1.430

TRC10-150 ug/mL Triclosanrespiration

-0.959

TRZ10-25 ug/mL Thioridazinerespiration

-0.450

Valinomycin0.5-10 uM Valinomycinrespiration

0.961

ZnSO42 mM ZnSO4respiration

0.495

menadione6-10 ug/mL Menadionerespiration

0.422

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.656

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.107

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.402

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.781

NRP_1Non-replicating persistence stage 1dosRassociated

0.941

Amp0.2mg/mL AmpicillincellWall

0.276

Cephalexin20-100 ug/mL CephalexincellWall

1.036

Cerulenin0.32-5 ug/mL CerulenincellWall

0.190

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.087

EMB10-20 ug/mL EthambutolcellWall

0.229

Eta12-40 ug/mL EthionamidecellWall

0.088

INH0.2-0.4 ug/mL IsoniazidcellWall

0.151

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.319

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.558

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.702

BZA0.12 mg/mL BenzamidearomaticAmides

-0.189

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.017

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.169

H2O24 mM hydrogen peroxideDNAdamaging

-0.209

Levo10 ug/mL LevofloxacinDNAdamaging

0.600

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.662

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.342

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.742

UVUV-irradiationDNAdamaging

0.153

ARP41-4 ug/mL Antitubercular compound ARP4?

0.371

Antimycin12.5-50 ug/mL Antimycin A?

0.346

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.068

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.118

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.259

PA8240.2-2 ug/mL PA-824?

-1.136

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.084

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.204

Verapamil50 uM Verapamil?

-0.354

mercaptoethanol2 mM 2-Mercaptoethanol?

0.694

methoxatin10-20 ug/mL Methoxatin?