from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3087/-

LFCtreatmentdescriptionclass of inhibitor

-0.536

Amikacinug/mL Amikacintranslation

-0.939

Cap5-10ug/mL Capreomycintranslation

-1.183

Rox10-50 ug/mL Roxithromycintranslation

-0.821

SM2-5 ug/mL Streptomycintranslation

-1.358

Tet5-10 ug/mL Tetracyclinetranslation

-0.209

Rif0.2-5ug/mL Rifampicintranscription

-0.490

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.575

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

2.013

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.090

CPZ10-50 ug/mL Chlorpromazinerespiration

0.443

Clofazimine10-13 ug/mL Clofaziminerespiration

0.061

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.381

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

2.627

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.563

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.042

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.955

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.056

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.656

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.237

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.737

KCN5-20 ug/mL Potassium cyaniderespiration

0.338

NaN30.2-2 mM Sodium aziderespiration

0.389

Nigericin50 uM Nigericinrespiration

1.311

TRC10-150 ug/mL Triclosanrespiration

0.824

TRZ10-25 ug/mL Thioridazinerespiration

-1.435

Valinomycin0.5-10 uM Valinomycinrespiration

1.137

ZnSO42 mM ZnSO4respiration

-1.027

menadione6-10 ug/mL Menadionerespiration

0.474

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.079

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.284

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.207

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.579

NRP_1Non-replicating persistence stage 1dosRassociated

-0.338

Amp0.2mg/mL AmpicillincellWall

-0.402

Cephalexin20-100 ug/mL CephalexincellWall

-0.244

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.343

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.495

EMB10-20 ug/mL EthambutolcellWall

-0.713

Eta12-40 ug/mL EthionamidecellWall

-0.675

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.742

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.071

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.536

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.316

BZA0.12 mg/mL BenzamidearomaticAmides

0.596

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.008

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.784

H2O24 mM hydrogen peroxideDNAdamaging

-0.701

Levo10 ug/mL LevofloxacinDNAdamaging

-1.003

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.212

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.621

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.662

UVUV-irradiationDNAdamaging

-0.724

ARP41-4 ug/mL Antitubercular compound ARP4?

3.686

Antimycin12.5-50 ug/mL Antimycin A?

-0.433

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.129

PA_110-50 ug/mL Antitubercular compound PA-1?

0.105

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.682

PA8240.2-2 ug/mL PA-824?

0.491

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.152

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.197

Verapamil50 uM Verapamil?

0.314

mercaptoethanol2 mM 2-Mercaptoethanol?

0.053

methoxatin10-20 ug/mL Methoxatin?