from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3079c/-

LFCtreatmentdescriptionclass of inhibitor

0.524

Amikacinug/mL Amikacintranslation

0.705

Cap5-10ug/mL Capreomycintranslation

0.408

Rox10-50 ug/mL Roxithromycintranslation

-0.631

SM2-5 ug/mL Streptomycintranslation

0.630

Tet5-10 ug/mL Tetracyclinetranslation

0.717

Rif0.2-5ug/mL Rifampicintranscription

-0.256

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.640

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.990

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.027

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.139

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.326

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.931

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

3.155

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.435

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.562

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.390

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.240

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.460

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.732

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.006

KCN5-20 ug/mL Potassium cyaniderespiration

0.203

NaN30.2-2 mM Sodium aziderespiration

-0.369

Nigericin50 uM Nigericinrespiration

0.911

TRC10-150 ug/mL Triclosanrespiration

1.877

TRZ10-25 ug/mL Thioridazinerespiration

0.133

Valinomycin0.5-10 uM Valinomycinrespiration

-1.048

ZnSO42 mM ZnSO4respiration

-0.340

menadione6-10 ug/mL Menadionerespiration

-0.551

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.500

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.038

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-1.071

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.561

NRP_1Non-replicating persistence stage 1dosRassociated

-0.649

Amp0.2mg/mL AmpicillincellWall

-0.456

Cephalexin20-100 ug/mL CephalexincellWall

-0.216

Cerulenin0.32-5 ug/mL CerulenincellWall

0.130

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.337

EMB10-20 ug/mL EthambutolcellWall

-0.609

Eta12-40 ug/mL EthionamidecellWall

-1.200

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.316

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.012

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.765

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.052

BZA0.12 mg/mL BenzamidearomaticAmides

-0.145

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.969

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.178

H2O24 mM hydrogen peroxideDNAdamaging

0.032

Levo10 ug/mL LevofloxacinDNAdamaging

-1.026

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.760

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.532

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.073

UVUV-irradiationDNAdamaging

0.168

ARP41-4 ug/mL Antitubercular compound ARP4?

0.156

Antimycin12.5-50 ug/mL Antimycin A?

-0.771

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.023

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.069

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.724

PA8240.2-2 ug/mL PA-824?

1.057

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.352

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.661

Verapamil50 uM Verapamil?

-0.319

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.816

methoxatin10-20 ug/mL Methoxatin?