from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3060c/-

LFCtreatmentdescriptionclass of inhibitor

-0.661

Amikacinug/mL Amikacintranslation

-0.590

Cap5-10ug/mL Capreomycintranslation

-0.116

Rox10-50 ug/mL Roxithromycintranslation

0.095

SM2-5 ug/mL Streptomycintranslation

-0.849

Tet5-10 ug/mL Tetracyclinetranslation

0.754

Rif0.2-5ug/mL Rifampicintranscription

-0.589

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.404

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.770

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.403

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.498

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.670

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.599

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.663

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.060

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.459

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.201

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.256

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.114

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.998

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.657

KCN5-20 ug/mL Potassium cyaniderespiration

0.020

NaN30.2-2 mM Sodium aziderespiration

0.611

Nigericin50 uM Nigericinrespiration

0.713

TRC10-150 ug/mL Triclosanrespiration

0.633

TRZ10-25 ug/mL Thioridazinerespiration

1.497

Valinomycin0.5-10 uM Valinomycinrespiration

0.121

ZnSO42 mM ZnSO4respiration

1.930

menadione6-10 ug/mL Menadionerespiration

-0.205

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.493

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.458

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.152

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.831

NRP_1Non-replicating persistence stage 1dosRassociated

-0.502

Amp0.2mg/mL AmpicillincellWall

-0.431

Cephalexin20-100 ug/mL CephalexincellWall

-0.162

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.607

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.611

EMB10-20 ug/mL EthambutolcellWall

-0.317

Eta12-40 ug/mL EthionamidecellWall

-1.056

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.240

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.678

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.918

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.105

BZA0.12 mg/mL BenzamidearomaticAmides

-0.037

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.128

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.182

H2O24 mM hydrogen peroxideDNAdamaging

0.039

Levo10 ug/mL LevofloxacinDNAdamaging

-0.674

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.996

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.323

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.458

UVUV-irradiationDNAdamaging

1.985

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.721

Antimycin12.5-50 ug/mL Antimycin A?

-0.498

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.622

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.079

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.701

PA8240.2-2 ug/mL PA-824?

0.934

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.250

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.379

Verapamil50 uM Verapamil?

-0.026

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.413

methoxatin10-20 ug/mL Methoxatin?