from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3043c/ctaD

LFCtreatmentdescriptionclass of inhibitor

-1.526

Amikacinug/mL Amikacintranslation

-1.010

Cap5-10ug/mL Capreomycintranslation

-3.320

Rox10-50 ug/mL Roxithromycintranslation

0.382

SM2-5 ug/mL Streptomycintranslation

-1.577

Tet5-10 ug/mL Tetracyclinetranslation

0.428

Rif0.2-5ug/mL Rifampicintranscription

-1.021

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.567

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.828

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.221

CPZ10-50 ug/mL Chlorpromazinerespiration

0.116

Clofazimine10-13 ug/mL Clofaziminerespiration

0.528

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.681

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.034

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.485

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.616

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.259

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.714

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.487

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.490

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.361

KCN5-20 ug/mL Potassium cyaniderespiration

0.605

NaN30.2-2 mM Sodium aziderespiration

1.257

Nigericin50 uM Nigericinrespiration

-1.065

TRC10-150 ug/mL Triclosanrespiration

-0.952

TRZ10-25 ug/mL Thioridazinerespiration

-2.940

Valinomycin0.5-10 uM Valinomycinrespiration

0.729

ZnSO42 mM ZnSO4respiration

0.548

menadione6-10 ug/mL Menadionerespiration

-0.004

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.257

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.057

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.164

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.379

NRP_1Non-replicating persistence stage 1dosRassociated

0.489

Amp0.2mg/mL AmpicillincellWall

0.146

Cephalexin20-100 ug/mL CephalexincellWall

0.560

Cerulenin0.32-5 ug/mL CerulenincellWall

0.220

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.563

EMB10-20 ug/mL EthambutolcellWall

1.399

Eta12-40 ug/mL EthionamidecellWall

1.809

INH0.2-0.4 ug/mL IsoniazidcellWall

0.949

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.093

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.696

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.053

BZA0.12 mg/mL BenzamidearomaticAmides

-0.022

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.011

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.079

H2O24 mM hydrogen peroxideDNAdamaging

0.065

Levo10 ug/mL LevofloxacinDNAdamaging

0.290

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.087

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.687

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.176

UVUV-irradiationDNAdamaging

-0.785

ARP41-4 ug/mL Antitubercular compound ARP4?

0.440

Antimycin12.5-50 ug/mL Antimycin A?

0.465

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.766

PA_110-50 ug/mL Antitubercular compound PA-1?

0.780

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.699

PA8240.2-2 ug/mL PA-824?

-0.717

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.088

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.159

Verapamil50 uM Verapamil?

0.165

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.260

methoxatin10-20 ug/mL Methoxatin?