from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3042c/serB2

LFCtreatmentdescriptionclass of inhibitor

-1.167

Amikacinug/mL Amikacintranslation

-1.970

Cap5-10ug/mL Capreomycintranslation

-2.782

Rox10-50 ug/mL Roxithromycintranslation

0.016

SM2-5 ug/mL Streptomycintranslation

-2.499

Tet5-10 ug/mL Tetracyclinetranslation

-0.094

Rif0.2-5ug/mL Rifampicintranscription

0.039

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.420

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.769

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.637

CPZ10-50 ug/mL Chlorpromazinerespiration

0.968

Clofazimine10-13 ug/mL Clofaziminerespiration

0.517

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-3.249

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.165

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.058

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.533

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.973

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.579

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.563

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.051

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.078

KCN5-20 ug/mL Potassium cyaniderespiration

0.562

NaN30.2-2 mM Sodium aziderespiration

-0.449

Nigericin50 uM Nigericinrespiration

-0.206

TRC10-150 ug/mL Triclosanrespiration

-0.146

TRZ10-25 ug/mL Thioridazinerespiration

-2.107

Valinomycin0.5-10 uM Valinomycinrespiration

-0.125

ZnSO42 mM ZnSO4respiration

0.623

menadione6-10 ug/mL Menadionerespiration

0.181

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.133

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.213

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.167

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.723

NRP_1Non-replicating persistence stage 1dosRassociated

0.496

Amp0.2mg/mL AmpicillincellWall

-0.192

Cephalexin20-100 ug/mL CephalexincellWall

-0.569

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.201

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.315

EMB10-20 ug/mL EthambutolcellWall

0.707

Eta12-40 ug/mL EthionamidecellWall

1.059

INH0.2-0.4 ug/mL IsoniazidcellWall

0.158

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.107

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.273

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.466

BZA0.12 mg/mL BenzamidearomaticAmides

0.676

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.385

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.143

H2O24 mM hydrogen peroxideDNAdamaging

-0.700

Levo10 ug/mL LevofloxacinDNAdamaging

0.018

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.554

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.300

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.215

UVUV-irradiationDNAdamaging

0.215

ARP41-4 ug/mL Antitubercular compound ARP4?

0.172

Antimycin12.5-50 ug/mL Antimycin A?

-0.175

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.518

PA_110-50 ug/mL Antitubercular compound PA-1?

0.005

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.044

PA8240.2-2 ug/mL PA-824?

0.071

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.199

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.393

Verapamil50 uM Verapamil?

-0.311

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.397

methoxatin10-20 ug/mL Methoxatin?