from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3037c/-

LFCtreatmentdescriptionclass of inhibitor

1.120

Amikacinug/mL Amikacintranslation

0.477

Cap5-10ug/mL Capreomycintranslation

0.908

Rox10-50 ug/mL Roxithromycintranslation

0.464

SM2-5 ug/mL Streptomycintranslation

1.431

Tet5-10 ug/mL Tetracyclinetranslation

-0.654

Rif0.2-5ug/mL Rifampicintranscription

-0.348

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.119

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.238

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.295

CPZ10-50 ug/mL Chlorpromazinerespiration

0.019

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.458

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.167

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.628

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.295

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.059

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.680

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.936

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.534

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.088

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.936

KCN5-20 ug/mL Potassium cyaniderespiration

-0.786

NaN30.2-2 mM Sodium aziderespiration

-0.868

Nigericin50 uM Nigericinrespiration

0.025

TRC10-150 ug/mL Triclosanrespiration

-1.058

TRZ10-25 ug/mL Thioridazinerespiration

-0.693

Valinomycin0.5-10 uM Valinomycinrespiration

-0.620

ZnSO42 mM ZnSO4respiration

-0.552

menadione6-10 ug/mL Menadionerespiration

-0.235

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.277

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.057

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.881

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-1.337

NRP_1Non-replicating persistence stage 1dosRassociated

0.608

Amp0.2mg/mL AmpicillincellWall

0.502

Cephalexin20-100 ug/mL CephalexincellWall

0.174

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.421

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.245

EMB10-20 ug/mL EthambutolcellWall

0.704

Eta12-40 ug/mL EthionamidecellWall

0.901

INH0.2-0.4 ug/mL IsoniazidcellWall

0.144

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.431

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.225

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.975

BZA0.12 mg/mL BenzamidearomaticAmides

0.748

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.956

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.585

H2O24 mM hydrogen peroxideDNAdamaging

-0.642

Levo10 ug/mL LevofloxacinDNAdamaging

-0.764

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.527

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.432

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.813

UVUV-irradiationDNAdamaging

-0.971

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.242

Antimycin12.5-50 ug/mL Antimycin A?

-0.412

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.482

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.356

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.298

PA8240.2-2 ug/mL PA-824?

0.363

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.278

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.378

Verapamil50 uM Verapamil?

0.052

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.673

methoxatin10-20 ug/mL Methoxatin?