from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3036c/TB22.2

LFCtreatmentdescriptionclass of inhibitor

-0.504

Amikacinug/mL Amikacintranslation

0.572

Cap5-10ug/mL Capreomycintranslation

0.868

Rox10-50 ug/mL Roxithromycintranslation

-0.508

SM2-5 ug/mL Streptomycintranslation

-0.666

Tet5-10 ug/mL Tetracyclinetranslation

-1.056

Rif0.2-5ug/mL Rifampicintranscription

-0.546

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.733

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.725

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

1.764

CPZ10-50 ug/mL Chlorpromazinerespiration

1.110

Clofazimine10-13 ug/mL Clofaziminerespiration

0.209

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.575

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-0.672

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.911

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.576

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.982

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.791

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.001

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

1.038

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.762

KCN5-20 ug/mL Potassium cyaniderespiration

-1.268

NaN30.2-2 mM Sodium aziderespiration

-0.177

Nigericin50 uM Nigericinrespiration

-0.808

TRC10-150 ug/mL Triclosanrespiration

0.912

TRZ10-25 ug/mL Thioridazinerespiration

-0.613

Valinomycin0.5-10 uM Valinomycinrespiration

1.834

ZnSO42 mM ZnSO4respiration

1.389

menadione6-10 ug/mL Menadionerespiration

0.329

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.061

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.568

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.227

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.751

NRP_1Non-replicating persistence stage 1dosRassociated

0.401

Amp0.2mg/mL AmpicillincellWall

0.085

Cephalexin20-100 ug/mL CephalexincellWall

0.426

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.381

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.195

EMB10-20 ug/mL EthambutolcellWall

0.228

Eta12-40 ug/mL EthionamidecellWall

0.283

INH0.2-0.4 ug/mL IsoniazidcellWall

0.279

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.200

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.152

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.405

BZA0.12 mg/mL BenzamidearomaticAmides

-0.546

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.547

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.636

H2O24 mM hydrogen peroxideDNAdamaging

-0.706

Levo10 ug/mL LevofloxacinDNAdamaging

0.347

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-1.879

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.071

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.003

UVUV-irradiationDNAdamaging

1.090

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.091

Antimycin12.5-50 ug/mL Antimycin A?

-0.096

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.670

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.579

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.729

PA8240.2-2 ug/mL PA-824?

-0.941

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.447

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.873

Verapamil50 uM Verapamil?

-0.327

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.048

methoxatin10-20 ug/mL Methoxatin?