from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv3007c/-

LFCtreatmentdescriptionclass of inhibitor

0.162

Amikacinug/mL Amikacintranslation

0.105

Cap5-10ug/mL Capreomycintranslation

0.049

Rox10-50 ug/mL Roxithromycintranslation

-0.727

SM2-5 ug/mL Streptomycintranslation

0.519

Tet5-10 ug/mL Tetracyclinetranslation

0.725

Rif0.2-5ug/mL Rifampicintranscription

0.121

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.623

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.904

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

0.133

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.754

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.304

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.434

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.229

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

4.003

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.669

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

1.874

NaN30.2-2 mM Sodium aziderespiration

1.480

Nigericin50 uM Nigericinrespiration

1.065

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

1.222

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.530

menadione6-10 ug/mL Menadionerespiration

0.409

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.606

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.129

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

1.196

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.734

NRP_1Non-replicating persistence stage 1dosRassociated

-0.731

Amp0.2mg/mL AmpicillincellWall

-0.273

Cephalexin20-100 ug/mL CephalexincellWall

-0.402

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.886

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.687

EMB10-20 ug/mL EthambutolcellWall

-0.534

Eta12-40 ug/mL EthionamidecellWall

-0.717

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.422

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.358

BZA0.12 mg/mL BenzamidearomaticAmides

-0.290

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.357

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.181

H2O24 mM hydrogen peroxideDNAdamaging

0.148

Levo10 ug/mL LevofloxacinDNAdamaging

-0.649

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.319

Oflox5-10 ug/mL OfloxacinDNAdamaging

-1.033

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.128

Antimycin12.5-50 ug/mL Antimycin A?

1.294

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.158

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.570

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.204

PA8240.2-2 ug/mL PA-824?

0.147

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.107

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

2.113

Verapamil50 uM Verapamil?

3.420

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.760

methoxatin10-20 ug/mL Methoxatin?