from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2960c/-

LFCtreatmentdescriptionclass of inhibitor

0.357

Amikacinug/mL Amikacintranslation

0.754

Cap5-10ug/mL Capreomycintranslation

0.684

Rox10-50 ug/mL Roxithromycintranslation

0.062

SM2-5 ug/mL Streptomycintranslation

0.361

Tet5-10 ug/mL Tetracyclinetranslation

0.434

Rif0.2-5ug/mL Rifampicintranscription

0.348

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.464

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.299

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.376

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.320

Clofazimine10-13 ug/mL Clofaziminerespiration

0.749

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-2.399

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.214

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.621

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.756

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.570

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.071

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.814

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.501

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.133

KCN5-20 ug/mL Potassium cyaniderespiration

0.766

NaN30.2-2 mM Sodium aziderespiration

0.289

Nigericin50 uM Nigericinrespiration

-1.032

TRC10-150 ug/mL Triclosanrespiration

-1.397

TRZ10-25 ug/mL Thioridazinerespiration

-0.491

Valinomycin0.5-10 uM Valinomycinrespiration

2.542

ZnSO42 mM ZnSO4respiration

-1.053

menadione6-10 ug/mL Menadionerespiration

0.023

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.662

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.107

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.976

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.235

NRP_1Non-replicating persistence stage 1dosRassociated

0.473

Amp0.2mg/mL AmpicillincellWall

0.196

Cephalexin20-100 ug/mL CephalexincellWall

0.722

Cerulenin0.32-5 ug/mL CerulenincellWall

0.060

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.219

EMB10-20 ug/mL EthambutolcellWall

1.041

Eta12-40 ug/mL EthionamidecellWall

0.941

INH0.2-0.4 ug/mL IsoniazidcellWall

0.282

TLM0.1-0.2 mg/mL ThiolactomycincellWall

1.075

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.019

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.515

BZA0.12 mg/mL BenzamidearomaticAmides

-0.182

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.288

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.136

H2O24 mM hydrogen peroxideDNAdamaging

0.431

Levo10 ug/mL LevofloxacinDNAdamaging

1.188

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-2.105

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.870

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.051

UVUV-irradiationDNAdamaging

-0.401

ARP41-4 ug/mL Antitubercular compound ARP4?

0.414

Antimycin12.5-50 ug/mL Antimycin A?

0.579

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.579

PA_110-50 ug/mL Antitubercular compound PA-1?

0.676

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.343

PA8240.2-2 ug/mL PA-824?

-1.419

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.163

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.684

Verapamil50 uM Verapamil?

0.281

mercaptoethanol2 mM 2-Mercaptoethanol?

0.352

methoxatin10-20 ug/mL Methoxatin?