from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2930/fadD26

LFCtreatmentdescriptionclass of inhibitor

1.207

Amikacinug/mL Amikacintranslation

1.541

Cap5-10ug/mL Capreomycintranslation

1.021

Rox10-50 ug/mL Roxithromycintranslation

1.294

SM2-5 ug/mL Streptomycintranslation

2.246

Tet5-10 ug/mL Tetracyclinetranslation

-0.013

Rif0.2-5ug/mL Rifampicintranscription

0.358

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.528

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.677

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.415

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.200

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.638

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-0.097

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.100

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.315

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.286

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.022

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.283

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.822

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.770

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.466

KCN5-20 ug/mL Potassium cyaniderespiration

-1.081

NaN30.2-2 mM Sodium aziderespiration

0.640

Nigericin50 uM Nigericinrespiration

-0.762

TRC10-150 ug/mL Triclosanrespiration

-0.974

TRZ10-25 ug/mL Thioridazinerespiration

2.292

Valinomycin0.5-10 uM Valinomycinrespiration

-1.251

ZnSO42 mM ZnSO4respiration

0.283

menadione6-10 ug/mL Menadionerespiration

0.746

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.093

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.491

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.715

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

1.516

NRP_1Non-replicating persistence stage 1dosRassociated

0.267

Amp0.2mg/mL AmpicillincellWall

-0.253

Cephalexin20-100 ug/mL CephalexincellWall

1.141

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.171

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.717

EMB10-20 ug/mL EthambutolcellWall

0.282

Eta12-40 ug/mL EthionamidecellWall

1.208

INH0.2-0.4 ug/mL IsoniazidcellWall

0.277

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.348

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.011

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.171

BZA0.12 mg/mL BenzamidearomaticAmides

-1.136

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.649

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.662

H2O24 mM hydrogen peroxideDNAdamaging

0.199

Levo10 ug/mL LevofloxacinDNAdamaging

0.755

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.267

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.632

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.558

UVUV-irradiationDNAdamaging

-0.313

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.391

Antimycin12.5-50 ug/mL Antimycin A?

-0.469

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.181

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.178

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.640

PA8240.2-2 ug/mL PA-824?

0.878

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.145

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.544

Verapamil50 uM Verapamil?

-0.360

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.132

methoxatin10-20 ug/mL Methoxatin?