from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2926c/-

LFCtreatmentdescriptionclass of inhibitor

1.375

Amikacinug/mL Amikacintranslation

1.191

Cap5-10ug/mL Capreomycintranslation

0.625

Rox10-50 ug/mL Roxithromycintranslation

0.033

SM2-5 ug/mL Streptomycintranslation

2.387

Tet5-10 ug/mL Tetracyclinetranslation

-0.339

Rif0.2-5ug/mL Rifampicintranscription

-1.338

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.628

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.580

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.335

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.960

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.365

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.671

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.651

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.407

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.134

Econazole10-24 ug/mL Econazole (azole drug)respiration

-1.415

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.337

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.635

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.239

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.791

KCN5-20 ug/mL Potassium cyaniderespiration

0.333

NaN30.2-2 mM Sodium aziderespiration

0.636

Nigericin50 uM Nigericinrespiration

1.185

TRC10-150 ug/mL Triclosanrespiration

0.011

TRZ10-25 ug/mL Thioridazinerespiration

-0.217

Valinomycin0.5-10 uM Valinomycinrespiration

-0.007

ZnSO42 mM ZnSO4respiration

-0.392

menadione6-10 ug/mL Menadionerespiration

-0.827

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.559

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.290

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.522

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.089

NRP_1Non-replicating persistence stage 1dosRassociated

0.224

Amp0.2mg/mL AmpicillincellWall

0.084

Cephalexin20-100 ug/mL CephalexincellWall

-0.793

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.468

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.181

EMB10-20 ug/mL EthambutolcellWall

0.607

Eta12-40 ug/mL EthionamidecellWall

0.791

INH0.2-0.4 ug/mL IsoniazidcellWall

0.100

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.104

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.012

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.278

BZA0.12 mg/mL BenzamidearomaticAmides

1.235

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

1.263

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.872

H2O24 mM hydrogen peroxideDNAdamaging

0.633

Levo10 ug/mL LevofloxacinDNAdamaging

-1.108

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.512

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.096

Oflox5-10 ug/mL OfloxacinDNAdamaging

-1.379

UVUV-irradiationDNAdamaging

-0.971

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.677

Antimycin12.5-50 ug/mL Antimycin A?

-0.435

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.159

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.683

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.544

PA8240.2-2 ug/mL PA-824?

1.061

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.057

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.551

Verapamil50 uM Verapamil?

-0.286

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.910

methoxatin10-20 ug/mL Methoxatin?