from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2924c/fpg

LFCtreatmentdescriptionclass of inhibitor

0.319

Amikacinug/mL Amikacintranslation

0.373

Cap5-10ug/mL Capreomycintranslation

0.119

Rox10-50 ug/mL Roxithromycintranslation

0.526

SM2-5 ug/mL Streptomycintranslation

1.332

Tet5-10 ug/mL Tetracyclinetranslation

0.171

Rif0.2-5ug/mL Rifampicintranscription

-0.058

Rifp0.1-0.5ug/mL Rifapentinetranscription

-1.870

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-0.557

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.081

CPZ10-50 ug/mL Chlorpromazinerespiration

1.512

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.185

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.181

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-1.272

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-1.772

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.368

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.101

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-0.245

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-1.412

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.870

KCN5-20 ug/mL Potassium cyaniderespiration

-1.763

NaN30.2-2 mM Sodium aziderespiration

0.524

Nigericin50 uM Nigericinrespiration

-0.415

TRC10-150 ug/mL Triclosanrespiration

-0.496

TRZ10-25 ug/mL Thioridazinerespiration

0.414

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

-0.799

menadione6-10 ug/mL Menadionerespiration

-0.277

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.303

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.520

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.359

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

2.143

NRP_1Non-replicating persistence stage 1dosRassociated

0.334

Amp0.2mg/mL AmpicillincellWall

0.177

Cephalexin20-100 ug/mL CephalexincellWall

-0.556

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.672

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.096

EMB10-20 ug/mL EthambutolcellWall

0.401

Eta12-40 ug/mL EthionamidecellWall

0.576

INH0.2-0.4 ug/mL IsoniazidcellWall

0.097

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.049

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.193

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.008

BZA0.12 mg/mL BenzamidearomaticAmides

0.101

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.562

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.253

H2O24 mM hydrogen peroxideDNAdamaging

0.394

Levo10 ug/mL LevofloxacinDNAdamaging

-0.462

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

2.278

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.293

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.330

UVUV-irradiationDNAdamaging

-1.985

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.316

Antimycin12.5-50 ug/mL Antimycin A?

0.089

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-1.245

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.465

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.908

PA8240.2-2 ug/mL PA-824?

0.389

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.158

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.399

Verapamil50 uM Verapamil?

0.667

mercaptoethanol2 mM 2-Mercaptoethanol?

0.163

methoxatin10-20 ug/mL Methoxatin?