from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2919c/glnB

LFCtreatmentdescriptionclass of inhibitor

-0.169

Amikacinug/mL Amikacintranslation

0.712

Cap5-10ug/mL Capreomycintranslation

0.974

Rox10-50 ug/mL Roxithromycintranslation

-0.972

SM2-5 ug/mL Streptomycintranslation

-0.355

Tet5-10 ug/mL Tetracyclinetranslation

0.090

Rif0.2-5ug/mL Rifampicintranscription

-0.091

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.613

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.381

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.559

CPZ10-50 ug/mL Chlorpromazinerespiration

1.574

Clofazimine10-13 ug/mL Clofaziminerespiration

0.180

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

2.883

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.424

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.743

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

0.333

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.222

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.060

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

1.094

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.478

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

2.245

KCN5-20 ug/mL Potassium cyaniderespiration

-0.110

NaN30.2-2 mM Sodium aziderespiration

-0.430

Nigericin50 uM Nigericinrespiration

0.133

TRC10-150 ug/mL Triclosanrespiration

1.145

TRZ10-25 ug/mL Thioridazinerespiration

1.046

Valinomycin0.5-10 uM Valinomycinrespiration

-1.392

ZnSO42 mM ZnSO4respiration

0.507

menadione6-10 ug/mL Menadionerespiration

0.373

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.520

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.579

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.733

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.511

NRP_1Non-replicating persistence stage 1dosRassociated

-0.754

Amp0.2mg/mL AmpicillincellWall

-0.598

Cephalexin20-100 ug/mL CephalexincellWall

-0.406

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.209

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.716

EMB10-20 ug/mL EthambutolcellWall

-1.356

Eta12-40 ug/mL EthionamidecellWall

-1.281

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.668

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.491

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.771

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.030

BZA0.12 mg/mL BenzamidearomaticAmides

-0.154

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.728

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.857

H2O24 mM hydrogen peroxideDNAdamaging

-0.519

Levo10 ug/mL LevofloxacinDNAdamaging

-0.433

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.111

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.679

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.758

UVUV-irradiationDNAdamaging

-0.124

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.002

Antimycin12.5-50 ug/mL Antimycin A?

-0.141

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.805

PA_110-50 ug/mL Antitubercular compound PA-1?

0.699

PA_2110-50 ug/mL Antitubercular compound PA-21?

0.073

PA8240.2-2 ug/mL PA-824?

0.687

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.588

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.226

Verapamil50 uM Verapamil?

0.374

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.550

methoxatin10-20 ug/mL Methoxatin?