from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2901c/-

LFCtreatmentdescriptionclass of inhibitor

-0.246

Amikacinug/mL Amikacintranslation

-0.602

Cap5-10ug/mL Capreomycintranslation

-0.501

Rox10-50 ug/mL Roxithromycintranslation

-0.025

SM2-5 ug/mL Streptomycintranslation

0.721

Tet5-10 ug/mL Tetracyclinetranslation

0.645

Rif0.2-5ug/mL Rifampicintranscription

-0.020

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.200

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

0.044

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.172

CPZ10-50 ug/mL Chlorpromazinerespiration

0.419

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.384

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.847

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.599

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.216

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.301

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.107

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.376

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.544

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.674

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

1.631

KCN5-20 ug/mL Potassium cyaniderespiration

0.337

NaN30.2-2 mM Sodium aziderespiration

-0.271

Nigericin50 uM Nigericinrespiration

0.569

TRC10-150 ug/mL Triclosanrespiration

-0.494

TRZ10-25 ug/mL Thioridazinerespiration

-0.807

Valinomycin0.5-10 uM Valinomycinrespiration

-0.939

ZnSO42 mM ZnSO4respiration

-0.349

menadione6-10 ug/mL Menadionerespiration

-0.139

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.337

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.280

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.475

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

-0.448

NRP_1Non-replicating persistence stage 1dosRassociated

0.144

Amp0.2mg/mL AmpicillincellWall

-0.509

Cephalexin20-100 ug/mL CephalexincellWall

-0.758

Cerulenin0.32-5 ug/mL CerulenincellWall

0.947

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.002

EMB10-20 ug/mL EthambutolcellWall

-0.450

Eta12-40 ug/mL EthionamidecellWall

-0.282

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.274

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.084

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.557

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

1.888

BZA0.12 mg/mL BenzamidearomaticAmides

1.673

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.770

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.780

H2O24 mM hydrogen peroxideDNAdamaging

-0.284

Levo10 ug/mL LevofloxacinDNAdamaging

-0.935

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.859

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.053

Oflox5-10 ug/mL OfloxacinDNAdamaging

-1.065

UVUV-irradiationDNAdamaging

0.268

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.929

Antimycin12.5-50 ug/mL Antimycin A?

-0.803

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.301

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.647

PA_2110-50 ug/mL Antitubercular compound PA-21?

1.355

PA8240.2-2 ug/mL PA-824?

0.719

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.530

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.085

Verapamil50 uM Verapamil?

-0.564

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.574

methoxatin10-20 ug/mL Methoxatin?