from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2891/-

LFCtreatmentdescriptionclass of inhibitor

-0.063

Amikacinug/mL Amikacintranslation

-0.819

Cap5-10ug/mL Capreomycintranslation

-0.089

Rox10-50 ug/mL Roxithromycintranslation

-0.340

SM2-5 ug/mL Streptomycintranslation

-0.270

Tet5-10 ug/mL Tetracyclinetranslation

0.955

Rif0.2-5ug/mL Rifampicintranscription

0.054

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.299

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

2.407

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.367

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.580

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.697

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.680

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.735

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.461

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.938

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.357

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

1.051

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.450

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.918

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-0.098

KCN5-20 ug/mL Potassium cyaniderespiration

0.390

NaN30.2-2 mM Sodium aziderespiration

-0.409

Nigericin50 uM Nigericinrespiration

0.982

TRC10-150 ug/mL Triclosanrespiration

0.951

TRZ10-25 ug/mL Thioridazinerespiration

-0.621

Valinomycin0.5-10 uM Valinomycinrespiration

-0.803

ZnSO42 mM ZnSO4respiration

0.560

menadione6-10 ug/mL Menadionerespiration

-0.224

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.555

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.132

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.265

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.943

NRP_1Non-replicating persistence stage 1dosRassociated

0.262

Amp0.2mg/mL AmpicillincellWall

-0.284

Cephalexin20-100 ug/mL CephalexincellWall

-0.651

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.170

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.085

EMB10-20 ug/mL EthambutolcellWall

-0.578

Eta12-40 ug/mL EthionamidecellWall

-1.012

INH0.2-0.4 ug/mL IsoniazidcellWall

0.548

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-1.107

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-0.838

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.729

BZA0.12 mg/mL BenzamidearomaticAmides

0.255

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

-0.572

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.230

H2O24 mM hydrogen peroxideDNAdamaging

0.016

Levo10 ug/mL LevofloxacinDNAdamaging

-0.700

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.011

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.624

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.778

UVUV-irradiationDNAdamaging

0.997

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.137

Antimycin12.5-50 ug/mL Antimycin A?

-0.501

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

-0.116

PA_110-50 ug/mL Antitubercular compound PA-1?

0.477

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.151

PA8240.2-2 ug/mL PA-824?

-0.280

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.321

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.186

Verapamil50 uM Verapamil?

0.980

mercaptoethanol2 mM 2-Mercaptoethanol?

-0.217

methoxatin10-20 ug/mL Methoxatin?