from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2890c/rpsB

LFCtreatmentdescriptionclass of inhibitor

1.589

Amikacinug/mL Amikacintranslation

1.717

Cap5-10ug/mL Capreomycintranslation

2.940

Rox10-50 ug/mL Roxithromycintranslation

1.153

SM2-5 ug/mL Streptomycintranslation

2.170

Tet5-10 ug/mL Tetracyclinetranslation

-0.252

Rif0.2-5ug/mL Rifampicintranscription

-0.629

Rifp0.1-0.5ug/mL Rifapentinetranscription

-0.825

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.625

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-1.097

CPZ10-50 ug/mL Chlorpromazinerespiration

-0.108

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.428

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

-1.491

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

-2.633

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

-0.373

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.501

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.396

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-1.586

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

-1.047

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.286

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

-1.589

KCN5-20 ug/mL Potassium cyaniderespiration

-0.864

NaN30.2-2 mM Sodium aziderespiration

0.401

Nigericin50 uM Nigericinrespiration

-0.846

TRC10-150 ug/mL Triclosanrespiration

-1.446

TRZ10-25 ug/mL Thioridazinerespiration

0.455

Valinomycin0.5-10 uM Valinomycinrespiration

0.371

ZnSO42 mM ZnSO4respiration

0.396

menadione6-10 ug/mL Menadionerespiration

0.006

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

0.529

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.493

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.530

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.378

NRP_1Non-replicating persistence stage 1dosRassociated

0.589

Amp0.2mg/mL AmpicillincellWall

0.578

Cephalexin20-100 ug/mL CephalexincellWall

0.644

Cerulenin0.32-5 ug/mL CerulenincellWall

0.298

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

0.285

EMB10-20 ug/mL EthambutolcellWall

0.363

Eta12-40 ug/mL EthionamidecellWall

0.489

INH0.2-0.4 ug/mL IsoniazidcellWall

0.498

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.179

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.116

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.072

BZA0.12 mg/mL BenzamidearomaticAmides

0.317

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.324

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.085

H2O24 mM hydrogen peroxideDNAdamaging

0.569

Levo10 ug/mL LevofloxacinDNAdamaging

0.810

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

-0.374

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.556

Oflox5-10 ug/mL OfloxacinDNAdamaging

0.361

UVUV-irradiationDNAdamaging

-0.443

ARP41-4 ug/mL Antitubercular compound ARP4?

0.574

Antimycin12.5-50 ug/mL Antimycin A?

0.448

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.334

PA_110-50 ug/mL Antitubercular compound PA-1?

0.481

PA_2110-50 ug/mL Antitubercular compound PA-21?

-2.259

PA8240.2-2 ug/mL PA-824?

-0.568

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

0.264

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.107

Verapamil50 uM Verapamil?

0.193

mercaptoethanol2 mM 2-Mercaptoethanol?

0.573

methoxatin10-20 ug/mL Methoxatin?