from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2879c/-

LFCtreatmentdescriptionclass of inhibitor

-0.212

Amikacinug/mL Amikacintranslation

-2.614

Cap5-10ug/mL Capreomycintranslation

-2.255

Rox10-50 ug/mL Roxithromycintranslation

-0.007

SM2-5 ug/mL Streptomycintranslation

-2.659

Tet5-10 ug/mL Tetracyclinetranslation

-0.053

Rif0.2-5ug/mL Rifampicintranscription

1.929

Rifp0.1-0.5ug/mL Rifapentinetranscription

1.114

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

1.760

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

0.018

CPZ10-50 ug/mL Chlorpromazinerespiration

0.740

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.244

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

1.709

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

1.574

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

0.784

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

-0.116

Econazole10-24 ug/mL Econazole (azole drug)respiration

-0.192

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

0.379

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

0.465

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

0.620

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.751

KCN5-20 ug/mL Potassium cyaniderespiration

0.332

NaN30.2-2 mM Sodium aziderespiration

-0.737

Nigericin50 uM Nigericinrespiration

0.500

TRC10-150 ug/mL Triclosanrespiration

1.521

TRZ10-25 ug/mL Thioridazinerespiration

-0.751

Valinomycin0.5-10 uM Valinomycinrespiration

-1.277

ZnSO42 mM ZnSO4respiration

0.400

menadione6-10 ug/mL Menadionerespiration

0.070

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.375

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

0.444

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

-0.717

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.407

NRP_1Non-replicating persistence stage 1dosRassociated

0.213

Amp0.2mg/mL AmpicillincellWall

-0.435

Cephalexin20-100 ug/mL CephalexincellWall

-0.290

Cerulenin0.32-5 ug/mL CerulenincellWall

-1.765

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.396

EMB10-20 ug/mL EthambutolcellWall

-0.593

Eta12-40 ug/mL EthionamidecellWall

-0.853

INH0.2-0.4 ug/mL IsoniazidcellWall

0.018

TLM0.1-0.2 mg/mL ThiolactomycincellWall

-0.418

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

-1.048

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.333

BZA0.12 mg/mL BenzamidearomaticAmides

0.226

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.059

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

0.121

H2O24 mM hydrogen peroxideDNAdamaging

0.015

Levo10 ug/mL LevofloxacinDNAdamaging

0.048

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.900

Novobiocin10 ug/mL NovobiocinDNAdamaging

-0.141

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.063

UVUV-irradiationDNAdamaging

1.169

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.297

Antimycin12.5-50 ug/mL Antimycin A?

-0.680

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.305

PA_110-50 ug/mL Antitubercular compound PA-1?

-0.088

PA_2110-50 ug/mL Antitubercular compound PA-21?

-1.143

PA8240.2-2 ug/mL PA-824?

-0.127

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.106

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

-0.613

Verapamil50 uM Verapamil?

-0.527

mercaptoethanol2 mM 2-Mercaptoethanol?

-1.239

methoxatin10-20 ug/mL Methoxatin?