from: Boshoff et al (2004). The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism. J Biol Chem.

Gene Expression Profile for Rv2875/mpt70

LFCtreatmentdescriptionclass of inhibitor

0.602

Amikacinug/mL Amikacintranslation

0.386

Cap5-10ug/mL Capreomycintranslation

1.290

Rox10-50 ug/mL Roxithromycintranslation

0.402

SM2-5 ug/mL Streptomycintranslation

-0.307

Tet5-10 ug/mL Tetracyclinetranslation

0.295

Rif0.2-5ug/mL Rifampicintranscription

-0.702

Rifp0.1-0.5ug/mL Rifapentinetranscription

0.000

Min_med__succinate_Minimal medium with succinate as sole carbon source as compared to growth in 7H9/ADC/Tween/glycerolstarvation

-1.076

CCCP10-50 uM Carbonyl cyanide 3-chlorophenylhydrazonerespiration

-0.352

CPZ10-50 ug/mL Chlorpromazinerespiration

0.000

Clofazimine10-13 ug/mL Clofaziminerespiration

-0.284

Clotrimazole10-24 ug/mL Clotrimazole (azole drug)respiration

0.000

DCCD20-100 uM Dicyclohexylcarbodiimiderespiration

0.000

DNP"0.5-2.5 mM 2,4-Dinitrophenol"respiration

1.329

DTT"1-2 mM 1,4-Dithio-DL-threitol"respiration

2.051

Econazole10-24 ug/mL Econazole (azole drug)respiration

0.000

GSNO_CFZ0.1 mM S-Nitrosoglutathione + 5 ug/mL Clofaziminerespiration

-0.624

GSNO_CPZ0.1 mM S-Nitrosoglutathione + 20-25 ug/mL Chlorpromazinerespiration

2.976

GSNO_KCN0.1mM S-Nitrosoglutathione + 5ug/mL potassium cyaniderespiration

-0.272

GSNO_menadione0.1 mM S-Nitrosoglutathione + 6-10 ug/mL menadionerespiration

0.000

KCN5-20 ug/mL Potassium cyaniderespiration

0.000

NaN30.2-2 mM Sodium aziderespiration

-0.748

Nigericin50 uM Nigericinrespiration

0.554

TRC10-150 ug/mL Triclosanrespiration

0.000

TRZ10-25 ug/mL Thioridazinerespiration

0.197

Valinomycin0.5-10 uM Valinomycinrespiration

0.000

ZnSO42 mM ZnSO4respiration

0.682

menadione6-10 ug/mL Menadionerespiration

0.146

Ascididemin_Nat_prod4-9 ug/mL Organic extract of Eudistoma amplumironLimitation

-0.323

Deferoxamine150-250 uM Deferoxamine mesylateironLimitation

-0.182

Dipyridyl"100-200 uM 2,2'-Bipyridyl"ironLimitation

0.994

GSNO0.02-0.1mM S-NitrosoglutathionedosRassociated

0.000

NRP_1Non-replicating persistence stage 1dosRassociated

0.016

Amp0.2mg/mL AmpicillincellWall

-0.611

Cephalexin20-100 ug/mL CephalexincellWall

0.766

Cerulenin0.32-5 ug/mL CerulenincellWall

-0.656

DIPED5-100 ug/mL DiisopropylethylenediaminecellWall

-0.575

EMB10-20 ug/mL EthambutolcellWall

0.010

Eta12-40 ug/mL EthionamidecellWall

-0.189

INH0.2-0.4 ug/mL IsoniazidcellWall

-0.354

TLM0.1-0.2 mg/mL ThiolactomycincellWall

0.000

PalmitateMinimal medium with palmitate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.000

SuccinateMinimal medium with succinate as sole C-source as compared to minimal medium with glucose as sole CsourcecarbonSource

0.845

BZA0.12 mg/mL BenzamidearomaticAmides

-0.110

Nam0.12 - 1.2 mg/mL NicotinamidearomaticAmides

0.343

PZA0.12-1.2 mg/mL PyrazinamidearomaticAmides

-0.515

H2O24 mM hydrogen peroxideDNAdamaging

-0.180

Levo10 ug/mL LevofloxacinDNAdamaging

-0.732

Mtm0.1-0.2 ug/mL Mitomycin CDNAdamaging

0.000

Novobiocin10 ug/mL NovobiocinDNAdamaging

0.299

Oflox5-10 ug/mL OfloxacinDNAdamaging

-0.538

UVUV-irradiationDNAdamaging

0.000

ARP41-4 ug/mL Antitubercular compound ARP4?

-0.038

Antimycin12.5-50 ug/mL Antimycin A?

2.027

DTNB"1-2 mM 5,5'-Dithiobis(2-nitrobenzoic acid)"?

0.368

PA_110-50 ug/mL Antitubercular compound PA-1?

0.483

PA_2110-50 ug/mL Antitubercular compound PA-21?

-0.576

PA8240.2-2 ug/mL PA-824?

-0.368

Procept_677620-30 ug/mL Antitubercular compound Procept 6776?

-0.286

Procept_67785-40 ug/mL Antitubercular compound Procept 6778?

0.000

Verapamil50 uM Verapamil?

0.000

mercaptoethanol2 mM 2-Mercaptoethanol?

3.591

methoxatin10-20 ug/mL Methoxatin?